宫腔镜电切术联合地屈孕酮对子宫内膜息肉患者炎症因子及复发情况的影响  

Effects of Hysteroscopic Electrocision Combined with Dydrogesterone on Inflammatory Factors and Recurrence in Patients with Endometrial Polyps

作　　者：杨杏玲 王群 危丽 YANG Xingling;WANG Qun;WEI Li(Department of Gynecology,Ruijin Maternal and Child Health Hospital,Ruijin 342500,China)

机构地区：[1]瑞金市妇幼保健院妇科,江西瑞金342500

出　　处：《中国医学创新》2025年第4期60-63,共4页Medical Innovation of China

摘　　要：目的:探究宫腔镜电切术联合地屈孕酮对子宫内膜息肉患者炎症因子及复发情况的影响。方法:选取瑞金市妇幼保健院2022年3月—2023年3月收治的88例子宫内膜息肉患者作为研究对象,进行回顾性分析。根据治疗方式不同将患者分为两组:单一组(n=42,采取宫腔镜电切术治疗)、联合组(n=46,采取宫腔镜电切术联合地屈孕酮治疗)。对比两组月经情况、子宫内膜厚度、炎症因子水平及复发情况。结果:术前两组月经情况及子宫内膜厚度比较,差异均无统计学意义(P>0.05);术后6个月,两组月经期均缩短,月经量均减少,子宫内膜厚度均减小,且联合组较单一组月经期短[(5.21±1.65)d vs(7.13±1.76)d]、月经量少[(64.47±8.75)mL vs(71.47±9.31)mL]、子宫内膜厚度小[(4.69±1.12)mm vs(6.12±1.88)mm],差异均有统计学意义(P<0.05)。术前两组炎症因子水平比较,差异均无统计学意义(P>0.05);术后1个月两组炎症因子水平均降低,且与单一组比较,联合组白细胞介素-6[(8.06±2.45)ng/L vs(9.65±3.01)ng/L]、C反应蛋白[(6.35±1.59)mg/L vs(7.31±1.66)mg/L]、肿瘤坏死因子-α[(3.04±0.98)ng/L vs(4.35±1.24)ng/L]水平均低,差异均有统计学意义(P<0.05)。联合组复发率低于单一组(4.35%vs 19.05%),差异有统计学意义(P<0.05)。结论:宫腔镜电切术联合地屈孕酮治疗子宫内膜息肉,可改善患者月经和子宫内膜情况,减轻炎症反应,降低复发率低。Objective:To investigate the effects of hysteroscopic electrocision combined with Dydrogesterone on inflammatory factors and recurrence in patients with endometrial polyps.Method:A total of 88 patients with endometrial polyps admitted to Ruijin Maternal and Child Health Hospital from March 2022 to March 2023 were selected as the research subjects for retrospective analysis.Patients were divided into two groups according to different treatment methods:single group(n=42,treated with hysteroscopic electrocision)and combined group(n=46,treated with hysteroscopic electrocision combined with Dydrogesterone).The menstrual condition,endometrial thickness,inflammatory factors levels and recurrence were compared between the two groups.Result:There were no significant differences in menstrual condition and endometrial thickness between the two groups before treatment(P>0.05).6 months after surgery,the menstrual period were shortened,the menstrual volume were reduced and the endometrial thickness were reduced in both groups,and compared with the single group,the menstrual period in combined group was shorter[(5.21±1.65)d vs(7.13±1.76)d],the menstrual volume was less[(64.47±8.75)mL vs(71.47±9.31)mL],and the endometrial thickness was smaller[(4.69±1.12)mm vs(6.12±1.88)mm],the differences were statistically significant(P<0.05).There were no statistically significant differences in the levels of inflammatory factors between the two groups before treatment(P>0.05).1 months after surgery,the levels of inflammatory factors in both groups were reduced,and compared with the single group,the levels of interleukin-6[(8.06±2.45)ng/L vs(9.65±3.01)ng/L],C reactive protein[(6.35±1.59)mg/L vs(7.31±1.66)mg/L]and tumor necrosis factor-α[(3.04±0.98)ng/L vs(4.35±1.24)ng/L]in combined group were lower,the differences were statistically significant(P<0.05).The recurrence rate of combined group was lower than that of single group(4.35%vs 19.05%),the difference was statistically significant(P<0.05).Conclusion:Hysteroscopic electrocisio

关 键 词：宫腔镜电切术 地屈孕酮 子宫内膜息肉 炎症因子 复发 

分 类 号：R713.4[医药卫生—妇产科学]