以FFR联合RFR指导介入治疗的决策在稳定性冠心病中的应用  

Application of FFR Combined with RFR to Guide Interventional Therapy Decision Making in Stable Coronary Heart Disease

作　　者：查贸孔 刘艳秋 汉荣 白玉云 ZHA Maokong;LIU Yanqiu;HAN Rong;BAI Yuyun(Department of Cardiology,Jisco Hospital,Jiayuguan 735100,China)

机构地区：[1]酒钢医院心内科,甘肃嘉峪关735100

出　　处：《中国医学创新》2025年第4期126-129,共4页Medical Innovation of China

基　　金：嘉峪关市科技计划项目(23-B08)。

摘　　要：目的:探究以血流储备分数(FFR)联合静息全周期比值(RFR)为指导的介入治疗决策对稳定性冠心病患者心血管不良事件及生存质量的影响。方法:将2021年10月—2022年6月酒钢医院收治的84例稳定性冠心病患者根据随机数字表法分为对照组和观察组,各42例。对照组以常规冠脉造影检查为指导进行治疗,观察组以FFR联合RFR为指导进行治疗。比较两组支架植入率、心血管不良事件发生率及再住院率、生存质量。结果:观察组的支架植入率显著低于对照组,差异有统计学意义(P<0.05);两组治疗后3、6、12个月的心血管不良事件发生率及再住院率比较,差异均无统计学意义(P>0.05);治疗前及治疗后6、12个月两组西雅图心绞痛量表评分比较,差异均无统计学意义(P>0.05);两组治疗后6、12个月的西雅图心绞痛量表评分均显著高于治疗前,差异均有统计学意义(P<0.05)。结论:以FFR联合RFR为指导的介入治疗在保证稳定性冠心病患者生存质量的同时可降低支架植入率,且不增加心血管不良事件发生风险。Objective:To investigate the effects of interventional therapy decision making guided by fractional flow reserve(FFR)combined with resting full-cycle ratio(RFR)on cardiovascular adverse events and quality of life in patients with stable coronary heart disease.Method:A total of 84 patients with stable coronary heart disease admitted to Jisco Hospital from October 2021 to June 2022 were divided into control group and observation group according to random number table method,with 42 cases in each group.The control group received treatment guided by routine coronary angiography,and the observation group received treatment guided by FFR combined with RFR.The stent implantation rate,the incidence of cardiovascular adverse events,the rate of re-hospitalization and the quality of life of the two groups were compared.Result:The stent implantation rate in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).There were no significant differences in the incidence of cardiovascular adverse events and the rate of re-hospitalization between the two groups 3,6 and 12 months after treatment(P>0.05).There were no significant differences in the scores of Seattle angina questionnaiire between the two groups before treatment and 6 and 12 months after treatment(P>0.05).The scores of Seattle angina questionnaiire 6 and 12 months after treatment were significantly higher than those before treatment,the differences were statistically significant(P<0.05).Conclusion:Interventional therapy guided by FFR combined with RFR can reduce the stent implantation rate while ensuring stable quality of life for patients with stable coronary heart disease,without increasing the risk of cardiovascular adverse events.

关 键 词：血流储备分数 静息全周期比值 介入治疗 稳定性冠心病 心血管不良事件 生存质量 

分 类 号：R541.4[医药卫生—心血管疾病]