涎液化糖链抗原-6在儿童特发性肺含铁血黄素沉着症中的诊断价值  

Diagnostic value of KL⁃6 detection in children diagnostic value of KL⁃6 detection in children with idio⁃pathic pulmonary hemosiderosis

作　　者：黄惠敏[1] 刘晨昕 方艳婷 郑佩燕[1] HUANG Huimin;LIU Chenxin;FANG Yanting;ZHENG Peiyan(Department of Clinical Laboratory of the First Affiliated Hospital of Guangzhou Medical University,State Key Laboratory of Respiratory Disease,National Center for Respiratory Medicine,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,Guangzhou 510120,Guangdong,China)

机构地区：[1]广州医科大学附属第一医院临床检验中心,呼吸疾病全国重点实验室,国家呼吸医学中心,国家呼吸系统疾病临床医学研究中心,广州呼吸健康研究院,广东广州510120

出　　处：《实用医学杂志》2025年第4期594-599,共6页The Journal of Practical Medicine

基　　金：广东省基础与应用基础研究项目(编号:2021B1515230008);广东省中医药局科研项目(编号:20231236);广东省钟南山基金会资助项目(编号:ZNSXS-20220083);广州市卫生健康科技一般引导项目(编号:20231A011082);呼吸疾病国家重点实验室自主课题资助项目(编号:SKLRD-Z-202305);南山人才项目(编号:2022111708151837)。

摘　　要：目的本研究旨在探讨涎液化糖链抗原-6(krebs von den lungen-6,KL-6)在特发性肺含铁血黄素沉着症(idiopathic pulmonary hemosiderosis,IPH)患儿辅助诊断中的临床应用价值。方法收集2014年6月至2024年7月期间于广州医科大学附属第一医院就诊的140例患儿,分为病例组与对照组,其中病例组根据疾病类型细分为IPH组(32例)、间质性肺炎(interstitial lung disease,ILD)组(22例)、肺炎(pneumonia,PN)组(60例),对照组为非肺部疾病(non-pulmonary disease,NPD)组(26例)。以上患儿检测血清KL-6水平,分析KL-6在各组患儿中的表达差异。结果KL-6阳性率在各组患儿中从高到低分别为IPH(68.75%)、ILD(45.45%)、PN(1.69%)和NPD(0.00%),组间阳性率差异有统计学意义(χ^(2)=66.10,P<0.001)。IPH组患儿血清KL-6平均水平高于PN组患儿(Ζ=-6.92,P<0.001)。诊断试验结果显示ROC曲线下面积为0.940(95%CI:0.89~1.00,P<0.001),截断值为392.00 U/mL,灵敏度为81.30%,特异度为95.00%。结论KL-6在鉴别IPH患儿与PN和NPD患儿中具有较高的诊断价值,可作为IPH辅助诊断的血液生物标志物。Objective To investigate the clinical utility of krebs von den lungen-6(KL-6),a sialoglycan antigen,in the auxiliary diagnosis of idiopathic pulmonary hemosiderosis(IPH)in children.Methods A total of 140 children admitted to the First Affiliated Hospital of Guangzhou Medical University from June 2014 to July 2024 were categorized into a case group and a control group.The case group was further subdivided into four subgroups based on disease type:IPH group(n=32),interstitial lung disease(ILD)group(n=22),pneumonia(PN)group(n=60),and non-pulmonary disease(NPD)group(n=26).Serum KL-6 levels were measured for all children across these groups,and the differences in KL-6 expression between children with IPH and those without IPH(including the ILD,PN,and NPD groups)were analyzed.Results The positive rates of KL-6 in each group of children,from highest to lowest,were as follows:IPH(68.75%),ILD(45.45%),PN(1.69%),and NPD(0.00%).The differences in positive rates between groups were statistically significant(χ^(2)=66.10,P<0.001).The mean serum level of KL-6 in the IPH group was significantly higher than that in the PN group(Z=-6.92,P<0.001).Diagnostic test results indicated that the area under the ROC curve was 0.940(95%CI:0.89 to 1.00,P<0.001),with a cut off value of 392.00 U/mL,sensitivity of 81.30%,and specificity of 95.00%.Conclusions KL-6 demonstrates significant diagnostic value in distinguishing IPH children from those with PN and NPD,making it a promising blood biomarker for aiding in the diagnosis of IPH.

关 键 词：KL-6 特发性肺含铁血黄素沉着症 儿童肺炎 生物标志物 

分 类 号：R44[医药卫生—诊断学]