前列地尔联合贝前列素钠治疗糖尿病周围神经病变的临床疗效及对其肢体症状的影响  

Clinical Efficacy of Alprostadil Combined with Beraprost Sodium in the Treatment of Diabetic Peripheral Neuropathy and its Effect on Limb Symptoms

作　　者：苏醒 SU Xing(The First Department of Internal Medicine,Yanshan County Hospital of Traditional Chinese Medicine,Yanshan 334500,Jiangxi,China)

机构地区：[1]铅山县中医院内一科,江西铅山334500

出　　处：《医学信息》2025年第2期136-139,共4页Journal of Medical Information

摘　　要：目的研究糖尿病周围神经病变患者应用前列地尔与贝前列素钠联合治疗的临床疗效及对其肢体症状的影响。方法采用随机数字表法将铅山县中医医院2021年3月-2023年7月收治的72例糖尿病周围神经病变患者分成对照组36例和研究组36例。对照组应用前列地尔治疗,研究组应用贝前列素钠和前列地尔联合治疗。比较两组临床疗效、神经传导速度[运动神经传导速度(MNCV)和感觉神经传导速度(SNCV)]、神经功能受损程度(TCSS评分)、血液流变学指标(血浆黏度、全血黏度低切、全血黏度高切)、肢体症状。结果研究组临床总有效率为94.44%,高于对照组的63.89%(P<0.05);两组治疗后正中神经、腓总神经MNCV、SNCV均快于治疗前,且研究组快于对照组(P<0.05);两组治疗后TCSS各项目评分、肢体症状各项目评分低于治疗前,且研究组低于对照组(P<0.05);两组治疗后血浆黏度、全血黏度低切、全血黏度高切水平低于治疗前,且研究组低于对照组(P<0.05)。结论前列地尔联合贝前列素钠治疗糖尿病周围神经病变的临床疗效确切,能够改善患者血液流变学指标,减轻患者肢体症状,提高患者神经功能。Objective To study the clinical efficacy of alprostadil combined with beraprost sodium in patients with diabetic peripheral neuropathy and its effect on limb symptoms.Methods A total of 72 patients with diabetic peripheral neuropathy admitted to Yanshan County Hospital of Traditional Chinese Medicine from March 2021 to July 2023 were divided into control group(36 patients)and study group(36 patients)by random number table method.The control group was treated with alprostadil,and the study group was treated with beraprost sodium and alprostadil.The clinical efficacy,nerve conduction velocity[motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)],neurological impairment(TCSS score),hemorheological indexes(plasma viscosity,whole blood viscosity low shear,whole blood viscosity high shear)and limb symptoms were compared between the two groups.Results The total clinical effective rate of the study group was 94.44%,which was higher than 63.89%of the control group(P<0.05).After treatment,MNCV and SNCV of median nerve and common peroneal nerve in the two groups were faster than those before treatment,and those in the study group were faster than those in the control group(P<0.05).After treatment,the scores of TCSS and limb symptoms in the two groups were lower than those before treatment,and those in the study group were lower than those in the control group(P<0.05).After treatment,the levels of plasma viscosity,whole blood viscosity low shear and whole blood viscosity high shear in the two groups were lower than those before treatment,and those in the study group were lower than those in the control group(P<0.05).Conclusion Alprostadil combined with beraprost sodium has a definite clinical effect in the treatment of diabetic peripheral neuropathy,which can improve the hemorheological indexes,relieve the limb symptoms and improve the neurological function of patients.

关 键 词：前列地尔 贝前列素钠 糖尿病周围神经病变 肢体症状 神经功能受损 血液流变学 

分 类 号：R587[医药卫生—内分泌]