黄芪颗粒联合丙酸氟替卡松吸入气雾剂对支气管哮喘患儿肺功能的影响  

The Effect of Huangqi Granules Combined with Fluticasone Propionate Inhalation Aerosol on Lung Function in Children with Bronchial Asthma

作　　者：李鹏 LI Peng(Department of Pediatrics,Yankuang New Journey General Hospital,Zoucheng 273500,China)

机构地区：[1]兖矿新里程总医院儿科,山东邹城273500

出　　处：《中国医学创新》2025年第5期1-5,共5页Medical Innovation of China

摘　　要：目的:研究黄芪颗粒联合丙酸氟替卡松吸入气雾剂对支气管哮喘患儿肺功能、T淋巴细胞亚群指标的影响。方法:选取兖矿新里程总医院2021年12月-2023年12月收治的86例支气管哮喘患儿,按照随机数字表法分成两组,各43例。对照组给予丙酸氟替卡松吸入气雾剂治疗,观察组给予黄芪颗粒联合丙酸氟替卡松吸入气雾剂治疗。比较两组的肺功能[用力肺活量(FVC)、呼气峰值流速(PEF)、第1秒用力呼气容积(FEV_(1))、第1秒用力呼气容积与用力肺活量的比值(FEV_(1)/FVC)、FEV_(1)占预计值百分比(FEV_(1)%pred)、最大呼气中期流量(MMEF)]、T淋巴细胞亚群指标[Th细胞(CD4^(+))和Ts细胞(CD8^(+))及其比值(CD4^(+)/CD8^(+))]、临床疗效、安全性。结果:治疗后,观察组的FVC、FEV_(1)、FEV_(1)/FVC、FEV_(1)%pred、PEF、MMEF、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)低于对照组,差异均有统计学意义(P<0.05);观察组总有效率高于对照组,差异有统计学意义(P<0.05);两组安全性比较差异无统计学意义(P>0.05)。结论:黄芪颗粒联合丙酸氟替卡松吸入气雾剂治疗支气管哮喘患儿可有效改善其肺功能,维持免疫平衡,提高治疗总有效率,安全性较高。Objective:To study the effect of Huangqi Granules combined with Fluticasone Propionate Inhalation Aerosol on lung function and T lymphocyte subsets in children with bronchial asthma.Method:A total of 86 children with bronchial asthma admitted to Yankuang New Journey General Hospital from December 2021 to December 2023 were selected and divided into two groups with 43 cases in each group according to the random number table method.The control group was treated with Fluticasone Propionate Inhalation Aerosol,and the observation group was treated with Huangqi Granules combined with Fluticasone Propionate Inhalation Aerosol.The lung function[forced vital capacity(FVC),peak expiratory flow rate(PEF),forced expiratory volume in 1 second(FEV_(1)),ratio of forced expiratory volume in 1 second to forced vital capacity(FEV_(1)/FVC),percentage of FEV_(1) percentage of expected value(FEV_(1)%pred),maximum mid-expiratory flow(MMEF)],T lymphocyte subset indexes[Th cells(CD4^(+))and Ts cells(CD8^(+))and their ratios(CD4^(+)/CD8^(+))],clinical efficacy and safety were compared between the two groups.Result:After treatment,the levels of FVC,FEV_(1),FEV_(1)/FVC,FEV_(1)%pred,PEF,MMEF,CD4^(+),CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and the CD8^(+) level was lower than that in the control group,the differences were statistically significant(P<0.05);the total effective rate in the observation group was higher than that in the control group(P<0.05);there was no significant difference in safety between the two groups(P>0.05).Conclusion:Huangqi Granules combined with Fluticasone Propionate Inhalation Aerosol in the treatment of children with bronchial asthma can effectively improve their lung function,maintain immune balance,improve the total effective rate of treatment,and have high safety.

关 键 词：支气管哮喘 患儿 黄芪颗粒 丙酸氟替卡松吸入气雾剂 肺功能 T淋巴细胞亚群 

分 类 号：R725.6[医药卫生—儿科]