浓缩生长因子对慢性创面愈合情况及创面组织生长因子的影响  

Effect of Concentrated Growth Factor on Chronic Wound Healing and Wound Tissue Growth Factor

作　　者：陈秋莹 陈和珍[1] 杨陆涛 CHEN Qiuying;CHEN Hezhen;YANG Lutao(Department of Burn Plastic Surgery and Wound Repair,Jiujiang NO.1 People's Hospital,Jiujiang 332000,China;不详)

机构地区：[1]九江市第一人民医院烧伤整形与创面修复科,江西九江332000

出　　处：《中国医学创新》2025年第5期5-9,共5页Medical Innovation of China

基　　金：九江市科技计划项目(S2023ZDYFN571)。

摘　　要：目的:探讨浓缩生长因子(concentrated growth factor,CGF)在慢性创面修复中的应用。方法:选取2024年1—9月九江市第一人民医院烧伤整形与创面修复科收治的60例慢性创面修复患者,按随机数字表法分为观察组和对照组,各30例。对照组给予创面修复常规治疗,观察组在对照组基础上额外给予CGF治疗。比较两组患者创面完全愈合时间、创面完全愈合率,并分别于治疗前后采用疼痛视觉模拟评分法(visual analogue scale,VAS)对患者疼痛程度进行评分,比较两组患者治疗前后创面表皮生长因子(epidermal growth factor,EGF)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、血小板衍生生长因子(platelet-derived growth factor,PDGF)、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)水平,并记录两组治疗期间不良反应发生情况。结果:观察组患者创面完全愈合时间早于对照组,差异有统计学意义(P<0.05);对照组和观察组患者创面完全愈合率分别为60.00%、83.33%,观察组明显高于对照组,差异有统计学意义(P<0.05);两组患者治疗后VAS评分较治疗前均降低,且观察组低于对照组,差异均有统计学意义(P<0.05);治疗后,两组患者EGF、VEGF、PDGF、bFGF水平均提升,且观察组均高于对照组,差异均有统计学意义(P<0.05);观察组患者不良反应发生率略高于对照组,但差异无统计学意义(P>0.05)。结论:CGF能加快慢性创面的愈合,更大程度上减轻患者疼痛感,促进患者创面生长因子再生,且安全可行。Objective:To investigate the application of concentrated growth factor(CGF)in chronic wound repair.Method:Sixty patients who underwent chronic wound repair in the Department of Burn Plastic Surgery and Wound Repair at Jiujiang NO.1 People's Hospital from January to September 2024 were selected.According to the random number table,patients enrolled were assigned to the observation group and the control group,30 cases in each group.The control group received conventional wound repair treatment,and the observation group received additional CGF treatment on the basis of the control group.The time of complete wound healing and complete wound healing rate of the two groups were compared,and the pain degree of the patients was scored by visual analogue scale(VAS)before and after treatment,epidermal growth factor(EGF)and vascular endothelial growth factor(VEGF)were compared between the two groups before and after treatment,levels of VEGF,platelet-derived growth factor Medical Innovation of China Vol.22,No.5 February,2025(PDGF),basic fibroblast growth factor(bFGF),the occurrence of adverse reactions during treatment was recorded in the two groups.Result:The time of complete wound healing in the observation group was earlier than that in the control group,the difference was statistically significant(P<0.05).After treatment,complete wound healing rates of the control group and observation group were 60.00%and 83.33%,the observation group was significantly higher than that of the control group,with a statistically significant difference(P<0.05).After treatment,VAS scores of both groups decreased,and that of observation group was lower than that of the control group,with statistically significant differences(P<0.05).After treatment,the levels of EGF,VEGF,PDGF and bFGF were increased in both groups,and the observation group were higher than those of the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions in the observation group was slightly higher than that in the control group,

关 键 词：慢性创面修复 浓缩生长因子 创面完全愈合率 视觉模拟评分法 不良反应 

分 类 号：R641[医药卫生—外科学]