早期活动干预联合气压疗法对重症急性胰腺炎患者凝血功能、炎症反应的影响  

Effects of Early Activity Intervention Combined with Barotherapy on Coagulation Function and Inflammatory Response in Patients with Severe Acute Pancreatitis

作　　者：陈红 CHEN Hong(Department of Critical Care Medicine,the Second Affiliated Hospital of University of South China,Hengyang 421001,China)

机构地区：[1]南华大学附属第二医院重症医学科,湖南衡阳421001

出　　处：《中国医学创新》2025年第5期81-85,共5页Medical Innovation of China

摘　　要：目的:探讨早期活动干预联合气压疗法对重症急性胰腺炎患者凝血功能、炎症反应的影响。方法:选取南华大学附属第二医院收治的重症急性胰腺炎患者104例,选取时间为2022年5月-2023年10月,根据随机数字表法将患者分为试验组和参照组,各52例。参照组采用常规护理干预,试验组在参照组基础上采用早期活动干预联合气压疗法。比较两组胃肠道功能恢复情况、干预前后凝血功能和炎症反应指标。结果:试验组排气恢复时间、排便恢复时间、腹胀缓解时间和肠鸣音恢复时间均早于参照组,差异均有统计学意义(P<0.05)。干预后试验组活化部分凝血活酶时间(activated partial thromboplastin time,APTT)和凝血酶原时间(prothrombin time,PT)均明显长于参照组,D-二聚体(D-dimer,D-D)水平低于参照组(P<0.05)。干预后试验组白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumour necrosis factor-α,TNF-α)和C反应蛋白(C reactive protein,CRP)水平均明显低于参照组,差异均有统计学意义(P<0.05)。结论:早期活动干预联合气压疗法可促进重症急性胰腺炎患者胃肠功能恢复,减轻炎症反应,改善凝血功能。Objective:To explore the effects of early activity intervention combined with barotherapy on coagulation function and inflammatory response in patients with severe acute pancreatitis.Method:A total of 104 patients with severe acute pancreatitis admitted to the Second Affiliated Hospital of University of South China from May 2022 to October 2023 were selected and divided into experimental group and reference group according to random number table method.The reference group was treated with routine nursing intervention,and the experimental group was treated with early activity intervention combined with barotherapy based on the reference group.The recovery of gastrointinal function,coagulation function and inflammatory response indexes before and after intervention were compared between the two groups.Result:The exhaust recovery time,defecation recovery time,abdominal bloating relief time and bowel sound recovery time of experimental group were earlier than those of reference group,the differences were statistically significant(P<0.05).After intervention,activated partial thromboplastin time(APTT)and prothrombin time(PT)of the experimental group were significantly longer than those of the reference group,the level of D-dimer(D-D)was lower than that of the reference group(P<0.05).After intervention,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C reactive protein(CRP)in the experimental group were significantly lower than those in the reference group,the differences were statistically significant(P<0.05).Conclusion:Early activity intervention combined with barotherapy can promote the recovery of gastrointestinal function in patients with severe acute pancreatitis,reduce inflammatory response and improve coagulation function.

关 键 词：早期活动干预 气压疗法 重症急性胰腺炎 炎症反应 

分 类 号：R473.5[医药卫生—护理学]