屈螺酮炔雌醇片联合加味生化颗粒对人工流产术后阴道出血及子宫内膜修复的影响  

Effect of Drospirenone Ethinyl Estradiol Tablets Combined with Modified Biochemical Granules on Vaginal Bleeding and Endometrial Repair after Induced Abortion

作　　者：张齐芳 ZHANG Qifang(Department of Gynecology,Macheng People's Hospital,Macheng 438300,China)

机构地区：[1]麻城市人民医院妇科,湖北麻城438300

出　　处：《中国医学创新》2025年第6期1-5,共5页Medical Innovation of China

摘　　要：目的:探究屈螺酮炔雌醇片联合加味生化颗粒对人工流产术后阴道出血的疗效及对子宫内膜修复的影响。方法:选取于2023年2月—2024年2月在麻城市人民医院就诊的人工流产术后阴道出血患者86例作为研究对象,按照随机数字表法分为观察组(n=43)和对照组(n=43)。两组患者均进行口服抗感染药物常规治疗,对照组口服屈螺酮炔雌醇片,观察组在此基础上使用加味生化颗粒治疗。比较两组患者中医证候积分、疗效、治疗后的尿人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)转阴率、阴道出血情况、子宫内膜厚度、子宫螺旋动脉血流动力学指标[血流搏动指数(pulsatility index,PI)、阻力指数(resistance index,RI)、子宫内膜螺旋动脉舒张期末流速(end-diastolic flow rate of the spiral endometrial artery,EDFR)、子宫内膜螺旋动脉峰值流速(peak endometrial spiral artery flow velocity,PSV)]。结果:治疗后观察组总有效率(93.02%)高于对照组(76.74%),治疗后,观察组中医证候各项目积分及总积分与对照组比较均更低(P<0.05),观察组患者尿hCG转阴率(90.70%)与对照组(86.05%)比较差异无统计学意义(P>0.05),观察组阴道出血的各项指标均优于对照组,子宫内膜厚度与对照组比较更厚,治疗后PI、EDFR、PSV值均高于对照组,且RI值低于对照组,差异均有统计学意义(P<0.05)。结论:屈螺酮炔雌醇片与加味生化颗粒联合治疗的方式对人工流产术后阴道出血的效果较好,且对子宫内膜有较好的修复效果。Objective:To explore the curative effect of Drospirenone Ethinyl Estradiol Tablets combined with Modified Biochemical Granules on vaginal bleeding after induced abortion and its impact on endometrial repair.Method:A total of 86 cases of vaginal bleeding after induced abortion in Macheng People's Hospital from February 2023 to February 2024 were selected as the research objects,they were divided into observation group(n=43)and control group(n=43)according to the random number table method.Patients in both groups were treated with conventional oral anti-infective drugs.The control group was given oral Drospirenone Ethinyl Estradiol Tablets,the observation group was treated with Modified Biochemical Granules on the basis of that.The TCM scores,curative effect,negative rate of human chorionic gonadotropin(hCG)in urine,vaginal bleeding,endometrial thickness,hemodynamic indexes of uterine spiral artery[blood flow pulsation index(PI),resistance index(RI),end-diastolic flow rate of the spiral endometrial artery(EDFR)and peak endometrial spiral artery flow velocity(PSV)]after the treatment were compared between the groups.Result:After treatment,the total effective rate in observation group(93.02%)was higher than that in control group(76.74%),after the treatment,scores for each item of TCM syndromes and the total score in observation group were lower than those in control group(P<0.05).There was no statistical difference in negative rate of hCG in urine of patients between observation group(90.70%)and control group(86.05%)(P>0.05).Vaginal bleeding indexes in observation group were better than those in control group,and the endometrial thickness was higher than that in control group,after treatment,the values of PI,EDFR and PSV were higher than those in control group,and the RI value was lower than that in control group,with statistical significance(P<0.05).Conclusion:Drospirenone Ethinyl Estradiol Tablets combined with Modified Biochemical Granules has a good therapeutic effect on vaginal bleeding after induced abortion,an

关 键 词：屈螺酮炔雌醇片 人工流产术 加味生化颗粒 阴道出血 子宫内膜修复 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]