小青龙汤合保元汤加减治疗慢性阻塞性肺疾病急性发作期外寒内饮证的效果  

Effect of Modified Xiaoqinglong Decoction Combined with Baoyuan Decoction on External Cold and Internal Drink Syndrome of Acute Attack of Chronic Obstructive Pulmonary Disease

作　　者：朱起储 张新花 张青妹 ZHU Qichu;ZHANG Xinhua;ZHANG Qingmei(Department of Respiratory Medicine,Datian County General Hospital,Datian 366100,China;不详)

机构地区：[1]大田县总医院呼吸内科,福建大田366100 [2]大田县总医院心血管内科,福建大田366100 [3]大田县总医院(南院区)康复科,福建大田366100

出　　处：《中国医学创新》2025年第6期120-124,共5页Medical Innovation of China

摘　　要：目的:探究慢性阻塞性肺疾病(COPD)急性发作期外寒内饮证患者采用小青龙汤合保元汤加减治疗的临床效果。方法:择取大田县总医院收治62例确诊为COPD急性发作期外寒内饮证患者,入院接受治疗时间为2023年4月—2024年1月,通过病历号随机抽签分组法分为试验组(n=31)、对照组(n=31)。对照组采用西医基础治疗,试验组在对照组治疗方案基础上增加小青龙汤合保元汤加减治疗,两组均治疗14 d,对比两组临床总有效率、肺功能指标、炎症因子指标、免疫球蛋白指标、不良反应发生率。结果:治疗后试验组总有效率显著高于对照组,差异有统计学意义(P<0.05);治疗后试验组肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC]水平均显著高于对照组,差异均有统计学意义(P<0.05);治疗后试验组炎症因子指标[降钙素原(PCT)、C反应蛋白(CRP)、白介素-6(IL-6)]水平均显著低于对照组,差异均有统计学意义(P<0.05);治疗后试验组免疫球蛋白指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]水平均显著高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:COPD急性发作期外寒内饮证患者采用小青龙汤合保元汤加减治疗效果显著,可改善肺功能,缓解炎症反应,调节免疫功能,用药安全性较高。Objective:To investigate the clinical effect of modified Xiaoqinglong Decoction combined with Baoyuan Decoction in the treatment of patients with external cold and internal drink syndrome during acute attack of chronic obstructive pulmonary disease(COPD).Method:A total of 62 patients diagnosed with external cold and internal drink syndrome during acute attack of COPD were selected from Datian County General Hospital and admitted for treatment from April 2023 to January 2024.They were divided into experimental group(n=31)and control group(n=31)by random drawing of medical record number.The control group was treated with western medicine,and the experimental group was treated with modified Xiaoqinglong Decoction and Baoyuan Decoction on the basis of the treatment regimen of the control group.Both groups were treated for 14 days,and the clinical effective rate,pulmonary function indexes,inflammatory factor indexes,immunoglobulin indexes and incidence of adverse reactions were compared between the two groups.Result:After treatment,the total effect rate of experimental group was significantly higher than that of control group,the difference was statistically significant(P<0.05).After treatment,the levels of indexes of lung function[forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),FEV1/FVC]in experimental group were significantly higher than those in control group,the differences were statistically significant(P<0.05).After treatment,the levels of indexes of inflammatory factors[procalcitonin(PCT),C reactive protein(CRP),interleukin-6(IL-6)]in experimental group were significantly lower than those in control group,with statistical significance(P<0.05).After treatment,the levels of indexes of immunoglobulin[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)]in experimental group were significantly higher than those in control group,with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:M

关 键 词：小青龙汤 保元汤 慢性阻塞性肺疾病 外寒内饮证 

分 类 号：R259[医药卫生—中西医结合]