重症新生儿呼吸窘迫综合征发病的相关影响因素logistic回归分析  

Logistic Regression Analysis of Related Influencing Factors of Severe Neonatal Respiratory Distress Syndrome

作　　者：董珊珊 熊梦云 DONG Shanshan;XIONG Mengyun(Neonatology Department,Jiujiang Maternal and Child Health Hospital,Jiujiang 332000,China;不详)

机构地区：[1]九江市妇幼保健院新生儿科,江西九江332000

出　　处：《中国医学创新》2025年第6期149-152,共4页Medical Innovation of China

摘　　要：目的:探讨重症新生儿呼吸窘迫综合征(NRDS)发病的相关影响因素。方法:回顾性选择2021年1月—2024年8月九江市妇幼保健院收治的171例NRDS患儿的临床资料,根据病情严重程度,将重症NRDS患儿纳入重症组(n=50),轻症NRDS患儿纳入为轻症组(n=121)。比较两组各项资料差异,将差异有统计学意义项目纳入logistic回归分析模型实施多因素分析,筛选重症NRDS发生的危险因素。结果:两组胎龄、宫内感染、妊娠并发症/合并症、分娩方式、胎儿宫内窘迫、产后肺表面活性物质(PS)应用比较,差异均有统计学意义(P<0.05);两组患儿性别、体重及产妇产次、年龄、不良孕产史、产前使用皮质激素、生殖道感染比较,差异均无统计学意义(P>0.05)。logistic回归分析显示,胎龄<34周、宫内感染、有妊娠并发症/合并症、剖宫产、胎儿宫内窘迫是重症NRDS发生高危因素(P<0.05),产后PS应用是其保护因素(P<0.05)。结论:重症NRDS发生是由胎龄、宫内感染、妊娠并发症/合并症、分娩方式、胎儿宫内窘迫、产后PS应用多因素作用结果,临床需加以重视。Objective:To investigate the related factors of severe neonatal respiratory distress syndrome(NRDS).Method:Clinical data of 171 children with NRDS admitted to Jiujiang Maternal and Child Health Hospital from January 2021 to August 2024 were retrospectively selected.According to the severity of the disease,children with severe NRDS were included in the severe group(n=50),and those with mild NRDS were included in the mild group(n=121).The data differences between the two groups were compared,and the items with statistical significance were included in the logistic regression analysis model for multi-factor analysis,and the risk factors for severe NRDS were screened.Result:There were statistically significant differences in gestational age,intrauterine infection,pregnancy complications/comorbidity,delivery mode,fetal intrauterine distress and postpartum pulmonary surfactant(PS)application between the two groups(P<0.05).There were no significant differences in gender,body weight,maternal birth time,age,adverse pregnancy history,prenatal corticosteroids and reproductive tract infection between the two groups(P>0.05).logistic regression analysis showed that gestational age<34 weeks,intrauterine infection,pregnancy complications/comorbidity,cesarean section,fetal intrauterine distress were the risk factors for severe NRDS(P<0.05),and postpartum PS use was the protective factor(P<0.05).Conclusion:The occurrence of severe NRDS is the result of multiple factors such as gestational age,intrauterine infection,pregnancy complications/comorbidity,delivery mode,fetal intrauterine distress and postpartum PS application,which should be paid attention to clinically.

关 键 词：新生儿呼吸窘迫综合征 胎儿宫内窘迫 宫内感染 

分 类 号：R722.1[医药卫生—儿科]