血清PCT、D-D在主动脉夹层患者中的表达及其临床意义  

Expression and Clinical Significance of Serum PCT and D-D in Patients with Aortic Dissection

作　　者：贾海蓉 周建军 JIA Hairong;ZHOU Jianjun(Department of Cardiovascular,Yiyang Central Hospital Affiliated to Hunan University of Chinese Medicine,Yiyang 413000,China;不详)

机构地区：[1]湖南中医药大学附属益阳中心医院心血管内科,湖南益阳413000

出　　处：《中国医学创新》2025年第6期166-169,共4页Medical Innovation of China

摘　　要：目的:探讨血清降钙素原(PCT)、D-二聚体(D-D)在主动脉夹层患者中的表达及其临床意义。方法:选取2022年1月—2023年12月湖南中医药大学附属益阳中心医院收治的101例主动脉夹层患者纳入主动脉夹层组,另选取同期50例健康体检者纳入对照组,检测并比较两组血清PCT、D-D水平,比较不同临床特征主动脉夹层患者血清PCT、D-D水平,并绘制受试者操作特征(ROC)曲线分析血清PCT、D-D对主动脉夹层的诊断价值。结果:主动脉夹层组血清PCT、D-D水平均高于对照组(P<0.05)。合并高血压主动脉夹层患者血清PCT、D-D水平均高于未合并高血压患者,Standford分型为A型主动脉夹层患者血清PCT、D-D水平均高于Standford分型为B型患者(P<0.05);不同性别、年龄、体重指数主动脉夹层患者血清PCT、D-D水平比较,差异均无统计学意义(P>0.05)。ROC曲线分析显示,血清PCT、D-D诊断主动脉夹层的AUC分别为0.843、0.901,敏感度分别为88.1%、89.1%,特异度分别为62.0%、70.0%。结论:血清PCT、D-D在主动脉夹层患者中表达水平升高,可作为预测主动脉夹层发生的敏感血清学指标。Objective:To investigate the expression and clinical significance of serum procalcitonin(PCT)and D-dimer(D-D)in patients with aortic dissection.Method:A total of 101 patients with aortic dissection admitted to Yiyang Central Hospital Affiliated to Hunan University of Chinese Medicine from January 2022 to December 2023 were selected to be included in the aortic dissection group,and another 50 healthy subjects during the same period were selected to be included in the control group.Serum PCT and D-D levels of the two groups were detected and compared.Serum PCT and D-D levels in patients with aortic dissection with different clinical characteristics were compared,and receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum PCT and D-D in aortic dissection.Result:Serum PCT and D-D levels in aortic dissection group were higher than those in control group(P<0.05).The serum PCT and D-D levels in patients with hypertensive aortic dissection were higher than those in patients without hypertensive aortic dissection,and the serum PCT and D-D levels in patients with Standford type A aortic dissection were higher than those with Standford type B dissection(P<0.05).There were no significant differences in serum PCT and D-D levels in patients with aortic dissection with different sex,age and body mass index(P>0.05).ROC curve analysis showed that the AUC of serum PCT and D-D for the diagnosis of aortic dissection was 0.843 and 0.901,the sensitivity was 88.1%and 89.1%,and the specificity was 62.0%and 70.0%,respectively.Conclusion:The expression levels of serum PCT and D-D are elevated in patients with aortic dissection,which can be used as sensitive serological indicators to predict the occurrence of aortic dissection.

关 键 词：主动脉夹层 降钙素原 D-二聚体 临床意义 

分 类 号：R543.1[医药卫生—心血管疾病]