痰湿体质与高尿酸血症及CD4^(+)T淋巴细胞亚群的关系研究  

Correlation between phlegm-damp constitution and hyperuricemia based on CD4^(+)T lymphocyte subsets

作　　者：曹凤娇[1] 杜梦梦 施晓军 康天伦 侯秀娟[1] CAO Fengjiao;DU Mengmeng;SHI Xiaojun;KANG Tianlun;HOU Xiujuan(Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学东方医院,北京100078 [2]北京中医药大学,北京100029

出　　处：《现代中西医结合杂志》2025年第2期177-184,共8页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：北京市丰台区临床重点专科(风湿科)项目(040104001009);国家中医药管理局“十二五”重点专科(预防保健科)项目。

摘　　要：目的从免疫角度探讨痰湿体质与高尿酸血症(HUA)的关系,揭示“体病相关”理论的生物学基础,为HUA及其并发症的防治提供新思路及科学依据。方法依据HUA及中医体质诊断标准及纳排标准,以2023年1—6月在北京中医药大学东方医院风湿科就诊的平和体质HUA患者20例为平和体质HUA组,痰湿体质HUA患者20例为痰湿体质HUA组,另选择同期体检的平和体质健康者20例为平和体质健康组。比较3组人群性别、年龄、外周静脉血单个核细胞(PBMC)中抗体标记的辅助性T细胞(Th1、Th2、Th17)、调节性T细胞(Treg)比例和Th17/Treg比值、Th1/Th2比值。结果3组人群性别、年龄比较差异均无统计学意义(P均>0.05)。痰湿体质HUA组Th1细胞比例、Th17/Treg比值、Th1/Th2比值均明显高于平和体质健康组(P均<0.05),Th17细胞比例明显高于平和体质健康组和平和体质HUA组(P均<0.05),Treg细胞比例明显低于平和体质健康组(P<0.05);平和体质HUA组Th1细胞比例、Th17细胞比例、Treg细胞比例、Th17/Treg比值、Th1/Th2比值与平和体质健康组比较差异均无统计学意义(P均>0.05);3组Th2细胞比例比较差异均无统计学意义(P均>0.05)。结论痰湿体质HUA患者存在更明显的免疫失衡现象,以Th1和Th17细胞介导的免疫反应增强为主,早期调节痰湿体质或可为HUA治疗提供新方向。Objective It is to explore the relationship between phlegm-dampness constitution and hyperuricemia(HUA)from an immunological perspective,aiming to elucidate the biological basis of the“constitution-disease correlation”theory and provide new insights and scientific evidence for the prevention and treatment of HUA and its complications.Methods A total of 60 participants were recruited from the physical examination and rheumatology departments of Dongfang Hospital of Beijing University of Chinese Medicine from January to June 2023.The participants were classified into 3 groups according to HUA and traditional Chinese medicine constitution diagnostic criteria:20 HUA patients with balanced constitution as balanced constitution HUA group,20 HUA patients with phlegm-dampness constitution as phlegm-dampness constitution HUA group,20 healthy people with balanced constitution as balanced constitution healthy group.The gender,age,proportion of antibody-labeled helper T cells(Th1,Th2,Th17),regulatory T cells(Treg),and Th17/Treg ratio and Th1/Th2 ratio in peripheral venous blood mononuclear cells(PBMCs)were compared among the three groups.Results There were no statistically significant differences in gender and age among the three groups(all P>0.05).The proportion of Th1 cells,Th17/Treg ratio and Th1/Th2 ratio in the phlegm-dampness constitution HUA group were significantly higher than those in the balanced constitution healthy group(all P<0.05),the proportion of Th17 cells was significantly higher than that in the balanced constitution healthy group and balanced constitution HUA group(all P<0.05),and the proportion of Treg cells was significantly lower than that in the balanced constitution healthy group(P<0.05);there were no significant differences in the proportions of Th1 cells,Th17 cells,Treg cells,Th17/Treg ratio and Th1/Th2 ratio between the balanced constitution HUA group and balanced constitution healthy group(all P>0.05);there was no significant difference in the proportion of Th2 cells among the three groups(al

关 键 词：高尿酸血症 痰湿体质 CD4^(+)T淋巴细胞亚群 免疫失衡 

分 类 号：R589.7[医药卫生—内分泌]