益气活血方治疗子宫内膜异位症痛经伴焦虑抑郁疗效观察  

Efficacy of decoction for replenishing Qi and activating blood on endometriosis dysmenorrhea with anxiety and depression

作　　者：沈聪 胡攀伟 杨梦琪 董静静 杨红[2] 张保华 张勤华[1] 齐聪[1] 章晓乐[1] SHEN Cong;HU Panwei;YANG Mengqi;DONG Jingjing;YANG Hong;ZHANG Baohua;ZHANG Qinhua;QI Cong;ZHANG Xiaole(Shuguang Hospital Affiliated to Shanghai University of Chinese Medicine,Shanghai 201210,China;Municipal Hospital Affiliated to Shanghai University of Chinese Medicine,Shanghai 200071,China;Shanghai Punan Hospital of Pudong New District,Shanghai 200125,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201210 [2]上海中医药大学附属市中医医院,上海200071 [3]浦东新区浦南医院,上海200125

出　　处：《现代中西医结合杂志》2025年第2期185-189,203,共6页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金面上项目(82274571);国家自然科学基金青年项目(82305283);国家中医药管理局第七批全国老中医专家学术继承计划。

摘　　要：目的观察益气活血方治疗子宫内膜异位症痛经伴焦虑抑郁患者的临床疗效。方法选择上海中医药大学附属曙光医院2021年1月—2022年6月诊治的92例子宫内膜异位症痛经伴焦虑抑郁患者,按照随机数字表平均分为中药组和对照组,每组46例。中药组给予益气活血方治疗,对照组给予布洛芬胶囊治疗,比较2组患者治疗前后不同时间点疼痛视觉模拟评分法(VAS)评分、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、血清糖类抗原125(CA125)水平、异位内膜囊肿体积及治疗期间不良反应发生情况。结果2组治疗1个月经周期、治疗3个月经周期后及停药后1个月经周期VAS评分、HAMA评分、HAMD评分和中药组停药后3个月经周期VAS评分、HAMA评分、HAMD评分均明显低于治疗前(P均<0.05);中药组治疗1个月经周期后VAS评分明显高于同期对照组(P<0.05),2组治疗3个月经周期后VAS评分比较差异无统计学意义(P>0.05),中药组停药后1个月经周期、停药后3个月经周期VAS评分及治疗1个月经周期、治疗3个月经周期后、停药后1个月经周期、停药后3个月经周期HAMA评分和HAMD评分均明显低于同期对照组(P均<0.05)。治疗3个月经周期后,中药组血清CA125水平及异位内膜囊肿体积均明显低于治疗前及同期对照组(P均<0.05)。中药组不良反应发生率为2.17%(1/46),对照组为6.52%(3/46),2组比较差异无统计学意义(P>0.05)。结论益气活血方可有效持久减轻子宫内膜异位症患者痛经程度及焦虑抑郁状态,且可抑制内异灶生长。Objective It is to observe the clinical efficacy of decoction for replenishing Qi and activating blood in the treatment of endometriosis(EMs)patients with dysmenorrhea complicating with anxiety and depression.Methods A total of 92 patients with EMs dysmenorrhea complicating with anxiety and depression treated in Shuguang Hospital Affiliated to Shanghai University of Chinese Medicine from January 2021 to June 2022 were randomly divided into Chinese medicine group and control group according to the random number table,with 46 patients in each group.The Chinese medicine group was treated with decoction for replenishing Qi and activating blood,and the control group was treated with ibuprofen capsule.The pain visual analog scale(VAS)scores,Hamilton anxiety scale(HAMA)scores,Hamilton depression scale(HAMD)scores,serum level of glycoantigen 125(CA125),ectopic endothelial cyst volume of patients in the two groups before and after treatment and the occurrence of adverse reactions during the treatment period were compared between the two groups.Results The VAS scores,HAMA scores,HAMD scores after 1 menstrual cycle of treatment,after 3 menstrual cycles of treatment,and after 1 menstrual cycle of withdrawal period in both groups and the VAS scores,HAMA scores,HAMD scores after 3 menstrual cycles of withdrawal period in the Chinese medicine group were significantly lower than those before treatment(all P<0.05);the VAS scores in the Chinese medicine group was significantly higher than that in the control group in the same period after 1 menstrual cycle of treatment(P<0.05),the difference in VAS scores after 3 menstrual cycles of treatment was not statistically significant between the two groups(P>0.05),the VAS scores after 1,3 menstrual cycles of withdrawal period,and HAMA scores and HAMD scores after 1,3 menstrual cycles of treatment,and after 1,3 menstrual cycles of withdrawal period in the Chinese medicine group were significantly lower than those in the control group in the same period(all P<0.05).After 3 menstrual cycles

关 键 词：益气活血方 子宫内膜异位症 痛经 焦虑 抑郁 

分 类 号：R711.71[医药卫生—妇产科学]