Association of non-alcoholic fatty liver disease with glycemic control among patients with type 2 diabetes mellitus at Limbe Regional Hospital,Southwest,Cameroon  

作　　者：Ebot Walter Ojong Moses Njutain Ngemenya Melvis Mwantem Tafili Elvis Asangbeng Tanue Eric Akum Achidi 

机构地区：[1]Medical Laboratory Science,Faculty of Health Sciences,University of Buea,Buea PO Box 63,Southwest,Cameroon [2]Department of Biochemistry and Molecular Biology,University of Buea,Buea PO Box 63,Southwest,Cameroon

出　　处：《World Journal of Hepatology》2025年第2期86-96,共11页世界肝病学杂志(英文)

摘　　要：BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease characterized by combinations of insulin resistance and insulin deficiency.Non-alcoholic fatty liver disease(NAFLD)is emerging as a public health problem worldwide and affects up to 70%of patients with T2DM.Although patients with T2DM have an increased risk of developing advanced liver disease compared to healthy individuals,varying prevalence rates of NAFLD among patients with T2DM,ranging from 34%to 94%,have been reported.AIM To determine prevalence and identify associated factors of NAFLD among Limbe patients with T2DM and evaluate correlation with glycemic control.METHODS A cross-sectional study was carried out from February to June 2024 among patients with T2DM.Gamma-glutamyl transferase(GGT)activity and serum triglycerides(TGs)were measured by spectrophotometry.NAFLD was diagnosed using the fatty liver index score.Data were analyzed using SPSS version 26.0 for Windows.Student’s t-test was used to compare the means of two groups.The χ^(2) test was applied to determine the association of NAFLD and T2DM.Logistic regression analysis was performed to identify predictors of NAFLD.P<0.05 was considered statistically significant.RESULTS Of the 150 patients with T2DM recruited for this study,63(58%)were females and the majority(84.7%)had good glycemic control(glycated hemoglobin<7%).Prevalence of NAFLD among patients with T2DM was 19%.Patients with NAFLD had significantly elevated levels of TGs,GGT,and increased body mass index and waist circumference compared to those without NAFLD.There was a significant association between NAFLD and glycemic control.Predictive factors of NAFLD among patients with T2DM were vegetable intake of less than three times per week[adjusted odds ratio(aOR):0.131,95%CI:0.020-0.839;P=0.032],central obesity(aOR:0.167,95%CI:0.037-0.748;P=0.019),and metformin treatment for T2DM(aOR:0.167,95%CI:0.037-0.718;P<0.001).CONCLUSION The prevalence of NAFLD in patients with T2DM in Limbe Regional Hospital was 19%.Age,central obe

关 键 词：Type 2 diabetes mellitus Non-alcoholic fatty liver disease Glycemic control Correlation FACTORS 

分 类 号：R587.1[医药卫生—内分泌] R575.5[医药卫生—内科学]