Thyroid hormone,immunoglobin and complements for predicting hepatocellular carcinoma development in patients with hepatitis B virus-related liver cirrhosis  

作　　者：Xue-Cheng Tong Kai Liu Ze-Yu Huang Xiu-Jun Zhang Yuan Xue 

机构地区：[1]Department of Infectious Diseases,Changzhou Third People’s Hospital,Changzhou Medical Center,Nanjing Medical University,Changzhou 213000,Jiangsu Province,China

出　　处：《World Journal of Hepatology》2025年第2期130-139,共10页世界肝病学杂志(英文)

基　　金：Supported by The Research Foundation of Jiangsu Province Administration of Traditional Chinese Medicine,No.MS2023088;The Science and Technology Project of Changzhou,No.CE20225040;The Research Foundation of Nanjing Medical University Changzhou Medical Center,No.CMCC202311;Leading Talent of Changzhou“The 14th Five-Year Plan”High-Level Health Talents Training Project,No.2022CZLJ021.

摘　　要：BACKGROUND Hepatocellular carcinoma(HCC)surveillance is crucial for patients with compensated cirrhosis(CC)and decompensated cirrhosis(DC).Increasing evidence has revealed a connection between thyroid hormone(TH)and HCC,although this relationship remains contentious.Complements and immunoglobulin(Ig),which serve as surrogates of cirrhosis-associated immune dysfunc-tion,are associated with the severity and outcomes of liver cirrhosis(LC).To date,there is a lack of evidence supporting the recommendation of TH,Ig,and com-plement tests in patients at high risk of HCC.AIM To assess the predictive value of TH,Ig,and complements for HCC development.METHODS Data from 142 patients,comprising 72 patients with CC and 70 patients with DC,were analysed as a training set.Among them,100 patients who underwent complement and Ig tests were considered for internal validation.Logistic regression was employed to identify independent risk factors for HCC development.RESULTS The median follow-up duration was 32(24-37 months)months.The incidence of HCC was significantly higher in the DC group(16/70,22.9%)compared to the CC group(3/72,4.2%)(χ^(2)=10.698,P<0.01).Patients with DC exhibited lower total tetraiodothyronine(TT4),total triiodothyronine(TT3),free triiodothyronine,complement C3,and C4(all P<0.01),and higher IgA and IgG(both P<0.01).In both CC and DC patients,TT3 and TT4 positively correlated with alanine transaminase(ALT),aspartate transaminase(AST),and gamma-glutamyl transpeptidase(GGT).IgG positively correlated with IgM,IgA,ALT,and AST,while it negatively correlated with C3 and C4.Multivariable analysis indicated that age,DC status,and GGT were independent risk factors for HCC development.CONCLUSION The predictive value of TH,Ig,and complements for HCC development is suboptimal.Age,DC,and GGT emerge as more significant factors during HCC surveillance in hepatitis B virus-related LC.

关 键 词：Thyroid hormone IMMUNOGLOBULIN COMPLEMENT Hepatocellular carcinoma Prediction 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学] R735.7