Global landscape of hepatic organoid research:A bibliometric and visual study  

作　　者：Tao Li Rong-Qiang Bo Jun Yan Nadia L Johnson Meng-Ting Liao Yuan Li Yan Chen Jie Lin Jian Li Fu-Hao Chu Xia Ding 

机构地区：[1]School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100700,China [2]Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China [3]Department of Histology and Embryology,School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,China [4]Institute of Regulatory Science for Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China

出　　处：《World Journal of Hepatology》2025年第2期225-237,共13页世界肝病学杂志(英文)

基　　金：Supported by National Natural Science Foundation of China,No.81630080,No.82305179,and No.82374181;The China Postdoctoral Science Foundation Grant,No.2019M650600;The Beijing University of Chinese Medicine“Decoding Traditional Chinese Medicine”Project,No.2023-JYB-JBZD-036;The Hefei National Research Center for Physical Sciences at the Microscale,No.KF2021104.

摘　　要：BACKGROUND Hepatic organoid-based modelling,through the elucidation of a range of in vivo biological processes and the recreation of the intricate liver microenvironment,is yielding groundbreaking insights into the pathophysiology and personalized medicine approaches for liver diseases.AIM This study was designed to analyse the global scientific output of hepatic organoid research and assess current achievements and future trends through bibliometric analysis.METHODS Articles were retrieved from the Web of Science Core Collection,and CiteSpace 6.3.R1 was employed to analyse the literature,including outputs,journals,and countries,among others.RESULTS Between 2010 and 2024,a total of 991 articles pertaining to hepatic organoid research were published.The journal Hepatology published the greatest number of papers,and journals with an impact factor greater than 10 constituted 60%of the top 10 journals.The United States and Utrecht University were identified as the most prolific country and institution,respectively.Clevers H emerged as the most prolific author,whereas Huch M had the highest number of cocitations,suggesting that both are ideal candidates for academic collaboration.Research on hepatic organoids has exhibited a progressive shift in focus,evolving from initial investigations into model building,differentiation research in stem cells,bile ducts,and progenitor cells,to a broader spectrum encompassing lipid metabolism,single-cell RNA sequencing,and therapeutic applications.The phrases exhibiting citation bursts from 2022 to 2024 include“drug resistance”,“disease model”,and“patient-derived tumor organoids”.CONCLUSION Research on hepatic organoids has increased over the past decade and is expected to continue to grow.Key research areas include applications for liver diseases and drug development.Future trends likely to gain focus include patient-derived tumour organoids,disease modelling,and personalized medicine.

关 键 词：Hepatic organoid Bibliometric analysis CiteSpace Web of Science Core Collection Three-dimensional culture 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学] G353.1[医药卫生—基础医学]