Efficacy of catheter-based ultrasound renal denervation in the treatment of hypertension  

作　　者：Yi-Chao Ou Xin-Yuan Peng Jing-Xi Yang Bo-Yu Chen Peng-Fei Chen Mao Liu 

机构地区：[1]Department of Cardiology,Cardiovascular Research Center,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan Province,China [2]Department of Clinical Medicine,North Sichuan Medical College,Nanchong 637000,Sichuan Province,China

出　　处：《World Journal of Clinical Cases》2025年第16期29-37,共9页世界临床病例杂志(英文)

基　　金：Supported by Sichuan Provincial Medical Research Youth Innovation Project,No.Q22063;Guang'an District People's Hospital Joint Development Research Project,No.2024 LHFZ04。

摘　　要：BACKGROUND Hypertension(HTN)is a prevalent chronic health condition that significantly increases the risk of cardiovascular diseases-associated mortalities.Despite the use of antihypertensive medications,numerous patients fail to achieve guidelinerecommended blood pressure(BP)targets.AIM To evaluates the efficacy of catheter-based ultrasound renal denervation(uRDN)for the treatment of HTN.METHODS Relevant studies were identified through searches in PubMed,Embase,the Cochrane Library,Web of Science,and China National Knowledge Infrastructure,with a cut-off date at April 1,2024.A random-effects model was employed in this study to mitigate potential biases.The risk of bias for included studies was assessed using the Cochrane Risk of Bias assessment tool.Statistical analyses were conducted using Review Manager version 5.3.This meta-analysis incorporated four studies encompassing a total of 627 patients.The reporting bias of this study was deemed acceptable.RESULTS Compared to the Sham group,the uRDN group demonstrated a significant reduction in daytime ambulatory systolic BP(SBP)[mean difference(MD)-3.87 mmHg,95%confidence interval(CI):-7.02 to-0.73,P=0.02],office SBP(MD-4.13 mmHg,95%CI:-7.15 to-1.12,P=0.007),and home SBP(MD-5.51 mmHg,95%CI:-8.47 to-2.55,P<0.001).However,there was no statistically significant reduction observed in either 24-hour or nighttime ambulatory SBP levels.Subgroup analysis shows that uRDN can significantly reduce the SBP in patients with non-resistant HTN(MD-6.19 mmHg,MD-6.00 mmHg,MD-7.72 mmHg,MD-5.02 mmHg,MD-3.61 mmHg).CONCLUSION The current evidence suggests that uRDN may effectively reduce home,office,and daytime SBP in patients with HTN,particularly in those with non-resistant HTN.

关 键 词：HYPERTENSION Renal denervation ULTRASOUND Randomized controlled trial META-ANALYSIS 

分 类 号：R544.1[医药卫生—心血管疾病]