Ten years of a pediatric living donor liver transplantation program in Brazil  

作　　者：Marco Aurélio Farina Junior Melina Utz-Melere Carolina Soares da Silva Luiza Salgado Nader Cristine Suzana Trein Angelica Maria Lucchese Mayara Machry Rodrigo Mariano Cristina Targa Ferreira Antônio Nocchi Kalil Flávia Heinz Feier 

机构地区：[1]Department of Hepatology and Liver Transplantation,Santa Casa de Porto Alegre,Porto Alegre 90050-170,Brazil [2]Department of Hepato-Biliary-Pancreatic Surgery and Liver Transplantation,Irmandade Santa Casa de Misericórdia de Porto Alegre,Porto Alegre 90020-090,Brazil [3]Department of Surgical Oncology,Santa Rita Hospital/Santa Casa de Misericórdia de Porto Alegre,Porto Alegre 90050-170,Rio Grande do Sul,Brazil

出　　处：《World Journal of Transplantation》2025年第2期127-137,共11页世界移植杂志(英文)

摘　　要：BACKGROUND Pediatric living-donor liver transplantation is considered a safe alternative for the treatment of children with end-stage liver disease.Experienced tertiary centers and specialized medical staff are necessary to ensure compatible long-term survival rates and quality-of-life for these children.AIM To report the results and the 10-year learning curve of a pediatric living-donor liver transplantation program.METHODS We conducted a retrospective cohort study of pediatric recipients from 2013 to 2023.Post-transplant outcomes and patient survival rates were compared between two 5-year periods of the program.RESULTS A total of 25 and 48 patients underwent transplantation in the first(2013-2017)and second period(2018-2023),respectively.Portal vein and hepatic artery thrombosis occurred in 11(15.1%)and seven(9.6%)patients,respectively.Biliary complications were observed in 39 of 73 patients(53.4%).A lower warm ischemia time was observed in the second period compared to the first(32.6±8.6 minutes vs 38.4±9.8 minutes,P=0.018,respectively).Patient survival rates at 1 and 5 years were 84%in the first period and 91.7%in the second period,with no significant difference(P=0.32).CONCLUSION The reported indications and outcomes align with the current literature.Our findings provide crucial evidence regarding the feasibility of establishing a living donor program with consistent results over time.

关 键 词：End-stage liver disease Liver transplant Living donor Pediatric hepatology Survival rate 

分 类 号：R726.5[医药卫生—儿科]