Significance of the neutrophil-to-lymphocyte ratio and the platelet-tolymphocyte ratio as prognostic predictors after liver transplantation  

作　　者：Marco Maria Pascale Francesco Frongillo Pierangelo Vasta Giuseppe Massimiani Erida Nure Salvatore Agnes 

机构地区：[1]General Surgery and Liver Transplantation Unit,Fondazione Policlinico Universitario Agostino Gemelli IRCCS,Rome 00168,Italy [2]Department of Surgery,Fondazione Policlinico Universitario Agostino Gemelli IRCCS,Rome 00168,Italy

出　　处：《World Journal of Transplantation》2025年第2期237-244,共8页世界移植杂志(英文)

摘　　要：BACKGROUND The use of biomarkers,such as the neutrophil-to-lymphocyte ratio(NLR)and the neutrophil-to-platelet ratio(NPR),has shown promise in evaluating early outcomes after medical,interventional,and surgical treatments.NLR has emer-ged as an indicator of systemic inflammation and physiological stress.NPR has emerged as a potential indicator of inflammation and thrombotic risk in the context of surgical and radiological procedures.AIM To analyze the correlation of NLR and NPR with the development of post-liver transplantation(LT)early complications after stratification for hepatocellular carcinoma diagnosis.METHODS Consecutive patients undergone LT between January 2019 and December 2023 were enrolled.Data regarding the concentration of hemoglobin and the differ-ential leukocyte count on postoperative days(POD)0,1,3,and 5 were collected.RESULTS The dataset included 161 consecutive patients undergone LT.Clavien-Dindo IV-V complications had a good correlation with NLR POD 1(P=0.05),NLR POD 3(P<0.001),NLR POD 7(P<0.001),NPR POD 3(P<0.001).In addition,the NPR ratio on POD 3 correlated with the onset of 30-day hemorrhage(P=0.009).Finally,30-day mortality had a significant association with the NLR POD 1(P=0.03)and with NLR POD 7(P=0.004),while NPR had a significant correlation with 30-day mortality in NPR POD 7(P=0.004).CONCLUSION The analysis of NLR and NPR are strictly correlated with Clavien-Dindo IV-V complications and 30-day post-LT death.

关 键 词：Liver transplantation Immunobiomarkers Neutrophil-to-lymphocyte ratio Neutrophil-to-platelet ratio Postoperative complications 

分 类 号：R73[医药卫生—肿瘤]