Increased risk of colorectal cancer in young males with higher cardiovascular risk:A nationwide population-based cohort study  

作　　者：Ji Hyun Song Su-Yeon Choi Young Sun Kim Sun Young Yang Kyung-Do Han 

机构地区：[1]Internal Medicine and Healthcare Research Institute,Seoul National University Hospital Healthcare System Gangnam Center,Seoul 06236,South Korea [2]Internal Medicine,Seoul National University Hospital,Seoul National University College of Medicine,Seoul 06236,South Korea [3]Department of Statistics and Actuarial Science,Soongsil University,Seoul 06978,South Korea

出　　处：《World Journal of Gastrointestinal Oncology》2025年第3期69-80,共12页世界胃肠肿瘤学杂志(英文)

摘　　要：BACKGROUND Although the link between cardiovascular disease(CVD)and various cancers is well-established,the relationship between CVD risk and colorectal cancer(CRC)remains underexplored.AIM To elucidate the relationship between CVD risk scores and CRC incidence.METHODS In this population-based cohort study,participants from the 2009 National Health Checkup were followed-up until 2020.The cardiovascular(CV)risk score was calculated as the sum of risk factors(age,family history of coronary artery disease,hypertension,smoking status,and high-density lipoprotein levels)with high-density lipoprotein(≥60 mg/dL)reducing the risk score by one.The primary outcome was incidence of newly diagnosed CRC.RESULTS Among 2526628 individuals,30329 developed CRC during a mean follow-up of 10.1 years.Categorized by CV risk scores(0,1,2,and≥3).CRC risk increased with higher CV risk scores after adjusting for covariates[(hazard ratio=1.155,95%confidence interval:1.107-1.205)in risk score≥3,P<0.001].This association individuals not using statins.Moreover,even in participants without diabetes,a higher CV risk was associated with an increased CRC risk.CONCLUSION Increased CV risk scores were significantly associated with higher CRC risk,especially among males,younger populations,and non-statin users.Thus,males with a higher CV risk score,even at a younger age,are recommended to control their risk factors and undergo individualized CRC screening.

关 键 词：Colorectal cancer Cardiovascular disease Cohort study Age GENDER 

分 类 号：R735.34[医药卫生—肿瘤]