Treatment of a rare and severe infection of central nervous system by Angiostrongylus cantonensis:A case report  

作　　者：Jian-Hui Zhao Wen-Ju Li Jie Jiao Ming-Xing Wang Xi-Mu Zhang Jian-Yuan Yin Wen-Zhi Hu Qing Song Jie Liu 

机构地区：[1]Department of Critical Care Medicine,Hainan Hospital of Chinese PLA General Hospital,Sanya 572013,Hainan Province,China [2]Department of Tropical Medicine,Hainan Hospital of Chinese PLA General Hospital,Sanya 572013,Hainan Province,China [3]Department of Disease Control and Prevention,96602 Hospital of Chinese People’s Liberation Army,Kunming 650233,Yunnan Province,China [4]Department of Burn and Plastic Surgery,Air Characteristic Medical Center affiliated to PLA Air Force Military Medical University,Beijing 100142,China

出　　处：《World Journal of Radiology》2025年第2期52-61,共10页世界放射学杂志(英文)

基　　金：Supported by the Hainan Provincial Natural Science Foundation of China,No.824MS173 and No.823MS165;the Project of Hainan Province Clinical Medical Center.

摘　　要：BACKGROUND Angiostrongylus cantonensis-induced acute parasitic infection is a rare food-borne disease in clinical practice.Lack of its specific laboratory markers and subsequent difficulty in detecting pathogens cause high misdiagnosis and missed diagnosis rates.CASE SUMMARY A 20-year-old male developed persistent neck and back pain after consuming raw snail meat,followed by urinary retention and low fever.After admission,the patient was misdiagnosed as viral infection and Mycobacterium tuberculosis in central nervous system.After detection of Angiostrongylus cantonensis in blood and cerebrospinal fluid by metagenomics next generation sequencing,albendazole was administered with ceftriaxone and methylprednisolone treatment simultaneously.With effective antiparasitic treatment,the patient weaned from mechanical ventilation successfully and transferred out of intensive care unit for hyperbaric oxygen and rehabilitation treatment.CONCLUSION This case highlights the diagnostic challenges of Angiostrongylus cantonensis infection and the importance of advanced sequencing techniques in identifying rare pathogens.

关 键 词：Angiostrongylus cantonensis Cerebrospinal meningitis Severe infection Central nervous system Metagenomics next generation sequencing Case report 

分 类 号：R532.1[医药卫生—内科学]