Metabolic improvement effects of jejunoileal side-to-side anastomosis in patients with type 2 diabetes and the glucagon-like peptide-1 mechanism  

作　　者：Jian Yang Cheng-Zhi Zhang Jiao-Jiao Wang Jing Zhang 

机构地区：[1]Department of Cardiology,The First College of Clinical Medical Science,China Three Gorges University and Yichang Central People’s Hospital,Yichang 443000,Hubei Province,China [2]Hubei Key Laboratory of Ischemic Cardiovascular Disease,Yichang 443000,Hubei Province,China [3]Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease,Yichang 443000,Hubei Province,China [4]Central Laboratory,The First College of Clinical Medical Science,China Three Gorges University and Yichang Central People’s Hospital,Yichang 443000,Hubei Province,China

出　　处：《World Journal of Diabetes》2025年第4期29-36,共8页世界糖尿病杂志(英文)

基　　金：Supported by the National Natural Science Foundation of China,No.82471616,No.82170418 and No.82271618;Natural Science Foundation of Hubei Province,No.2022CFA015;Central Guiding Local Science and Technology Development Project,No.2022BGE237;Key Research and Development Program of Hubei Province,No.2022BCE001 and No.2023BCB139;Hubei Provincial Health Commission Project,No.WJ2023M151。

摘　　要：Wang et al explored the metabolic improvement effects of jejunoileal side-to-side anastomosis in patients with type 2 diabetes mellitus(T2DM),focusing on its multitarget metabolic regulatory potential through enhanced secretion of glucagon-like peptide-1.This surgical procedure alters the direction of nutrient flow,activates distal ileal L cells,and increases endogenous glucagon-like peptide-1 levels,supporting glucose homeostasis,enhancing insulin sensitivity,regulating body weight,and improving cardiovascular health.This structural adjustment transforms the gastrointestinal tract into an active endocrine regulatory organ,providing a pathway for metabolic improvement in patients with T2DM and other complex metabolic disorders.Although this procedure demonstrates significant metabolic improvements within 3-6 months after surgery,integrating hormone level measurements,metabolic marker analysis,and long-term follow-up has become crucial for exploring the complex mechanisms of T2DM in the field of metabolic surgery and T2DM management.Multidisciplinary collaboration involving support from endocrinology,nutrition,and rehabilitation teams before and after surgery is becoming increasingly vital in the long-term management of patients with T2DM.This collaboration optimizes surgical outcomes and enhances metabolic management.Side-to-side anastomosis shows potential in the multitarget metabolic management of T2DM,providing an additional intervention option for patients with T2DM and metabolic disorders.

关 键 词：Type 2 diabetes mellitus Jejunoileal side-to-side anastomosis Roux-en-Y gastric bypass Glucagon-like peptide-1 Bariatric surgery Multidisciplinary care 

分 类 号：R587.1[医药卫生—内分泌]