Effect of systolic blood pressure status on coronary inflammation and high-risk plaque characteristics  

作　　者：Cui-Ping Jiang Yuan-Kang Liu Pan-Pan Cheng Yue Dong Xiang Wang Fan-Yu Wu Yu-Xuan Xia Peng-Yun Wang Xiang-Yang Xu 

机构地区：[1]Department of Radiology,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430060,Hubei Province,China [2]Department of Radiology,Taihe Hospital,Hubei University of Medicine,Wuhan 442700,Hubei Province,China [3]Department of Radiology,The Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430014,Hubei Province,China [4]Department of Laboratory Medicine,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430060,Hubei Province,China

出　　处：《World Journal of Diabetes》2025年第4期128-143,共16页世界糖尿病杂志(英文)

基　　金：Supported by Natural Science Foundation of Hubei Province,No.2023AFB848.

摘　　要：BACKGROUND Inadequately controlled hypertension often leads to an increased cardiovascular death rate in type 2 diabetes mellitus(T2DM).It remains unclear whether systolic blood pressure(SBP)status of hypertension is related to coronary inflammation and plaques in T2DM.AIM To evaluate whether SBP variability(SBPV)and levels of hypertension are related to coronary inflammation and plaques in T2DM patients using coronary computed tomography angiography(CCTA).METHODS This retrospective study involved 881 T2DM patients with CCTA images,including 668 hypertension and 213 normotension patients.Hypertension patients were subgroup based on SBP status:(1)SBPV:Low(<8.96 mmHg)and high(≥8.96 mmHg)groups;and(2)SBP levels:Controlled(<140 mmHg)and uncontrolled(≥140 mmHg)groups.Pericoronary adipose tissue(PCAT)attenuation,high-risk plaques(HRPs)and obstructive stenosis(OS)were evaluated by CCTA.Propensity score matching was utilized to compare these CCTA findings for these groups.The impact of SBPV and SBP levels of hypertension on these CCTA findings in T2DM patients were evaluated by multivariate logistic regression and multivariable linear regression.RESULTS PCAT attenuation of the left anterior descending artery(LAD),any low attenuation plaque(LAP),any spotty calcification(SC),any positive remodeling(PR),and OS had significant differences between the hypertension group and the normotension group,as well as between the high SBPV or uncontrolled SBP group and the low SBPV or controlled SBP group(all P<0.05).Hypertension was independently positively correlated with LADPCAT attenuation(β=1.815,P=0.010),LAP(OR=1.612,P=0.019),SC(OR=1.665,P=0.013),PR(OR=1.549,P=0.033),and OS(OR=1.928,P=0.036)in all T2DM patients.Additionally,high SBPV and uncontrolled SBP were independently positively correlated with LAD-PCAT attenuation(high SBPV:β=1.673,P=0.048;uncontrolled SBP:β=2.370,P=0.004)and PR(high SBPV:OR=1.903,P=0.048;uncontrolled SBP:OR=2.230,P=0.013)in T2DM patients with hypertension.CONCLUSION Inadequately controlled hypertensi

关 键 词：Type 2 diabetes mellitus HYPERTENSION Coronary computed tomography angiography Pericoronary adipose tissue attenuation High-risk plaques 

分 类 号：R587.1[医药卫生—内分泌]