Clinical utility of glycated albumin and 1,5-anhydroglucitol in the screening and prediction of diabetes:A multi-center study  

作　　者：Kam-Ching Ku Junda Zhong Erfei Song Carol Ho-Yi Fong Karen Siu-Ling Lam Aimin Xu Chi-Ho Lee Chloe Yu-Yan Cheung 

机构地区：[1]Cheung,Department of Medicine,University of Hong Kong,Hong Kong 999077,China [2]State Key Laboratory of Pharmaceutical Biotechnology,University of Hong Kong,Hong Kong 999077,China [3]Guangdong-Hong Kong Joint Institute of Metabolic Medicine,University of Hong Kong,Hong Kong 999077,China

出　　处：《World Journal of Diabetes》2025年第4期178-188,共11页世界糖尿病杂志(英文)

基　　金：Supported by the Hong Kong Research Grants Council Area of Excellence,No.AoE/M/707-18.

摘　　要：BACKGROUND Despite being the gold standard,the use of glycated hemoglobin(HbA1c)and fasting plasma glucose(FPG)for diagnosing dysglycemia is imperfect.In particular,a low level of agreement between HbA1c and FPG in detecting prediabetes and diabetes has led to difficulties in clinical interpretation.Glycated albumin(GA)and 1,5-anhydroglucitol(1,5-AG)may potentially serve as biomarkers for the detection and prediction of diabetes,as well as glycemic monitoring.AIM To explore the diagnostic performance of GA and 1,5-AG for screening dysglycemia;assess whether they can be used for glycemic monitoring in Chinese morbidly-obese patients;and examine their predictive ability for incident diabetes in a Chinese community-based cohort.METHODS GA and 1,5-AG concentrations were measured in 462 morbidly-obese patients from the Obese Chinese Cohort(OCC).A sub-group of diabetes subjects(n=24)was prospectively followed-up after bariatric surgery.Differences between baseline and post-surgery biomarker values were converted to percentage change from baseline to assess the response to glycemic control.Predictive ability of the biomarkers was assessed in 132 incident diabetes cases and 132 matched non-diabetes controls in the community-based Cardiovascular Risk Factor Prevalence Study(CRISPS).A prediction model was developed and compared with clinical models based on conventional risk factors.RESULTS GA exhibited an excellent diagnostic value with an area under the receiver operating characteristic curve(AUC)of 0.919(95%CI:0.884-0.955)for identifying diabetes and a high agreement in the classification of diabetes with both FPG and HbA1c in the OCC.GA demonstrated the fastest response to glycemic control.In CRISPS,the‘B3A’prediction model,which consisted of body mass index(BMI)and 3 biomarkers(HbA1c,GA and 1,5-AG),achieved a comparable predictive value[AUC(95%CI):0.793(0.744-0.843)]to that of a clinical model comprising BMI,HbA1c,FPG and 2-hour glucose(2hG)[AUC(95%CI):0.783(0.733-0.834);DeLong P value=0.736].The‘B3A’was signi

关 键 词：DIABETES Biomarkers PREDICTION Glycated albumin 1 5-ANHYDROGLUCITOL 

分 类 号：R587.1[医药卫生—内分泌]