Double-edged sword of L-arginine in diabetes:Exploring antiinflammatory and antioxidant strategies  

作　　者：Shuai Liu Ning Li Jia-Jia Jin Yong-Wei Yu 

机构地区：[1]Department of Cardiology,The First People’s Hospital of Jiashan,Jiaxing 314100,Zhejiang Province,China [2]Department of Cardiology,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,Zhejiang Province,China [3]Intensive Care Unit,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,Zhejiang Province,China

出　　处：《World Journal of Diabetes》2025年第4期314-317,共4页世界糖尿病杂志(英文)

摘　　要：The article by Mansouri et al provides a comprehensive investigation into the effects of L-arginine(L-Arg)on diabetic cardiomyopathy.The authors conclude that while a low dose(0.5 g/kg)of L-Arg improves lipid profiles and reduces body weight,higher doses(≥1 g/kg)exacerbate oxidative stress,inflammation,and myocardial damage.In this letter,we aim to expand on the potential role of anti-inflammatory and antioxidant strategies in mitigating these adverse effects.Specifically,we focus on nuclear factor erythroid 2-related factor 2 activation and nitric oxide synthase modulation.These strategies could enhance the clinical utility of L-Arg by preserving its metabolic benefits while reducing its cardiotoxic risks.We believe this perspective will stimulate future research on L-Arg-based therapies in patients with diabetes,with an emphasis on optimizing dosage and exploring synergistic co-therapies.

关 键 词：L-ARGININE Diabetic cardiomyopathy Oxidative stress Nuclear factor erythroid 2-related factor 2 Nitric oxide synthase 

分 类 号：R58[医药卫生—内分泌]