窄谱中波紫外线照射联合胸腺肽肠溶片治疗对玫瑰糠疹患者VCAM-l和ICAM-1水平的影响  

Effect of narrow-band ultraviolet B phototherapy combined with enteric-coated thymopeptide on VCAM-1 and ICAM-1 in patients with pityriasis rosea

作　　者：俞锦舒 顾冬玲 许卫华 张敏敏 Yu Jinshu;Gu Dongling;Xu Weihua;Zhang Minmin(Department of Dermatology,Haimen District People’s Hospital,Nantong 226100,China)

机构地区：[1]海门区人民医院皮肤科,江苏南通226100

出　　处：《海军医学杂志》2025年第2期179-183,共5页Journal of Navy Medicine

基　　金：江苏省自然科学基金青年基金项目(BK20210050)。

摘　　要：目的评估窄谱中波紫外线照射联合胸腺肽肠溶片治疗对玫瑰糠疹患者的疗效对血管细胞黏附分子-1(VCAM-1)和细胞间黏附分子-1(ICAM-1)的影响。方法选取2022年9月至2024年2月南通市海门区人民医院皮肤科80例玫瑰糠疹患者作为研究对象。通过随机数字表法将患者分为治疗组(41例)和对照组(39例)。对照组接受窄谱中波紫外线照射治疗,治疗组接受窄谱中波紫外线照射联合胸腺肽肠溶片治疗,2组均治疗1个月。比较2组患者的疗效、皮疹相关时间变化、症状改善情况,并对比治疗前后的玫瑰糠疹严重程度评分(PRSS评分)、VCAM-1和ICAM-1水平及不良反应发生情况。结果治疗组的治疗总有效率高于对照组,且治疗组的皮疹停发时间和消退时间短于对照组,而皮疹止痒时间更长,差异有统计学意义(均P<0.05);治疗后,治疗组的PRSS评分、VCAM-1和ICAM-1水平低于对照组(P<0.05);治疗组与对照组的不良反应发生率差异无统计学意义(P>0.05)。结论窄谱中波紫外线照射联合胸腺肽肠溶片有助于提高玫瑰糠疹患者疗效,降低VCAM-1和ICAM-1水平。Objective To evaluate the efficacy of narrow-band ultraviolet B(NB-UVB)phototherapy combined with enteric-coated thymopeptide in treatment of pityriasis rosea and its impacts on vascular cell adhesion molecule-1(VCAM-1)and intercellular adhesion molecule-1(ICAM-1).Methods Eighty patients with pityriasis rosea who were admitted to Haimen District People’s Hospital from September 2022 to February 2024 were selected as research objects.They were divided into treatment group(n=41)and control group(n=39)according to random number table method.The control group was treated with NB-UVB phototherapy for one month,and the treatment group received NB-UVB phototherapy and enteric-coated thymopeptide for one month.The efficacy,rash-related time changes,symptom improvement,Pityriasis Rosea Severity Score(PRSS),VCAM-1 and ICAM-1 levels,and adverse events were compared between the two groups.Results The total effective rate of the treatment group was higher than that of the control group.The skin rash came to a halt and disappeared in a shorter time in the treatment group than in the control group,while the time to itch cessation in the treatment group was significantly longer than that in the control group(all P<0.05).The PRSS scores and levels of VCAM-1 and ICAM-1 in the treatment group were lower than those in the control group after treatment(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion NB-UVB phototherapy combined with enteric-coated thymopeptide can enhance the therapeutic effects on pityriasis rosea and reduce VCAM-1 and ICAM-1 levels.

关 键 词：玫瑰糠疹 窄谱中波紫外线照射 胸腺肽肠溶片 血管细胞黏附分子-1 细胞间黏附分子-1 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]