脉冲电场消融在室性心律失常治疗中的最新进展  

Advances in pulsed field ablation for treating ventricular arrhythmias

作　　者：于丰源 唐闽 YU Fengyuan;TANG Min(Arrhythmia Center,Fuwai Hospital,Chinese Academy of Medical Sciences,Beijing 100037,China)

机构地区：[1]中国医学科学院、北京协和医学院、国家心血管病中心、心血管疾病国家重点实验室、阜外医院心律失常中心,北京100037

出　　处：《实用心电与临床诊疗》2025年第1期1-5,共5页PRACTICAL ELECTROCARDIOLOGY AND CLINICAL TREATMENT

基　　金：国家自然科学基金委联合基金项目(U1913210)。

摘　　要：脉冲电场是一种新型心脏导管消融能量源,其通过高压脉冲电场在细胞膜上穿孔,导致细胞凋亡或坏死。脉冲电场消融(pulsed field ablation,PFA)具有(相对)特异性损伤心肌、迅速制造损伤且不依赖变温制造损伤等优势,已广泛用于心房颤动的导管消融治疗。目前,PFA的前沿研究正在向室性心律失常进军。本文结合近年来的研究结果,对PFA在室性心律失常治疗中的最新进展进行综述。Pulsed electric field is an emerging energy source for cardiac catheter ablation.It creates pores in the cell membrane through high-voltage pulsed electric field,leading to cell apoptosis or necrosis.Pulsed field ablation(PFA)offers several advantages,including relatively selective myocardial injury,rapid lesion formation,and temperature-independent lesion creation.It has been widely applied in catheter ablation therapy for atrial fibrillation.Currently,cutting-edge research on PFA is advancing into the field of ventricular arrhythmias.This article reviews the latest developments in PFA for the treatment of ventricular arrhythmias based on recent research findings.

关 键 词：脉冲电场消融 室性心律失常 导管消融 冠状动脉痉挛 

分 类 号：R692[医药卫生—泌尿科学] R540.41[医药卫生—外科学]