血清内皮素-1、Klotho、ROCK2水平与IgA肾病严重程度及预后的相关性  

Correlation of serum ET-1,Klotho and ROCK2 levels with severity and prognosis of IgA nephropathy

作　　者：邵二丽 肖雨 SHAO Erli;XIAO Yu(Department of Nephrology,Puyang Huimin Hospital,Puyang Henan 457099,China)

机构地区：[1]濮阳惠民医院肾内科,河南濮阳457099

出　　处：《实用心电与临床诊疗》2025年第1期89-93,共5页PRACTICAL ELECTROCARDIOLOGY AND CLINICAL TREATMENT

摘　　要：目的探究血清内皮素-1(endothelin-1,ET-1)、Klotho蛋白、Rho相关卷曲螺旋形成蛋白激酶2(Rho associated coiled coilforming protein kinase 2,ROCK2)水平与IgA肾病严重程度及预后的相关性。方法回顾性分析95例IgA肾病患者的临床资料,根据病情严重程度分为轻度、中度、重度,再依据2年后的预后情况将患者分为预后良好组和预后不良组;另选取同期健康体检者95例为对照组。对比两组、不同病情严重程度及不同预后患者血清ET-1、Klotho、ROCK2水平。分析上述指标与患者病情严重程度及预后的相关性,及其对患者预后不良的预测价值。结果IgA肾病组血清ET-1、ROCK2水平明显高于对照组,血清Klotho水平明显低于对照组(均P<0.05)。重度患者血清ET-1、ROCK2水平明显高于中度、轻度患者,中度患者亦明显高于轻度患者;重度患者血清Klotho水平则明显低于中度、轻度患者,中度患者亦明显低于轻度患者(均P<0.05)。与预后良好组比较,预后不良组血清ET-1、ROCK2水平均明显升高,血清Klotho水平则明显降低(均P<0.01)。血清ET-1、ROCK2水平与病情严重程度、预后呈正相关,血清Klotho水平与其呈负相关(均P<0.01)。血清ET-1、Klotho、ROCK2水平联合检测预测患者预后不良的曲线下面积(AUC)为0.826,约登指数为0.560,明显高于三项指标单独预测的AUC值和约登指数(均P<0.01)。结论血清ET-1、Klotho、ROCK2水平与IgA肾病患者病情严重程度及预后关系密切,各指标联合检测可为临床预后预测提供参考。Objective To explore the correlation of serum endothelin-1(ET-1),Klotho protein and Rho associated coiled coilforming protein kinase 2(ROCK2)levels with the severity and prognosis of IgA nephropathy.Methods The clinical data of 95 patients with IgA nephropathy were retrospectively selected.They were categorized into mild,moderate,and severe groups based on the disease severity.Patients were divided into good and poor prognosis groups according to their prognosis after 2 years.Another 95 healthy physical examinees in the same period were selected as the control group.The levels of serum ET-1,Klotho and ROCK2 were compared between the two groups,patients with different disease severity,and patients with different prognosis.The correlation of the levels of the above indicators with the disease severity and prognosis was analyzed,as well as the predictive value for poor prognosis of patients.Results The levels of serum ET-1 and ROCK2 in the IgA nephropathy group were significantly higher than those in the control group,while the level of serum Klotho was significantly lower than that in the control group(all P<0.05).The serum ET-1 and ROCK2 levels were significantly higher in severe patients than those in moderate and mild patients,while the levels in moderate patients were also significantly higher than those in mild patients.The serum Klotho level in severe patients were significantly lower than that in moderate and mild patients,while its level in moderate patients was also significantly lower than that in mild patients(all P<0.05).Compared with the good prognosis group,the levels of serum ET-1 and ROCK2 in the poor prognosis group were both significantly increased,while the level of serum Klotho protein was significantly decreased(all P<0.01).The levels of serum ET-1 and ROCK2 were positively correlated with the severity and prognosis of the disease,while the level of serum Klotho was negatively correlated with the severity and prognosis(all P<0.01).The AUC value of the combined detection of serum ET-1,Klotho,and

关 键 词：IGA肾病 内皮素-1 KLOTHO蛋白 Rho相关卷曲螺旋形成蛋白激酶2 预后 

分 类 号：R692.6[医药卫生—泌尿科学]