2,3,5-三取代咪唑衍生物的高效合成方法  

An efficient protocol for the synthesis of 2,3,5-trisubstituted imidazole derivatives

作　　者：杨峥 丛兴顺[3] 陈益武[1] 张刚[1,2] 解恒参 YANG Zheng;CONG Xing-shun;CHEN Yi-wu;ZHANG Gang;XIE Heng-shen(School of Architectural Intelligence,Jiangsu Vocational Institute of Architectural Technology,Xuzhou 221116,China;Jiangsu Collaborative Innovation Center for Building Energy Saving and Construct Technology,Xuzhou 221116,China;College of Chemistry,Chemical Engineering and Materials Science,Zaozhuang University,Zaozhuang 277160,China)

机构地区：[1]江苏建筑职业技术学院建筑智能学院,江苏徐州221116 [2]江苏建筑节能与建造技术协同创新中心,江苏徐州221116 [3]枣庄学院化学化工与材料科学学院,山东枣庄277160

出　　处：《兰州理工大学学报》2025年第1期66-71,共6页Journal of Lanzhou University of Technology

基　　金：山东省自然科学基金(ZR2022QB093,ZR2022MB027);江苏省高等学校自然科学研究面上项目(24KJB530008);江苏建筑节能与建造技术协同创新中心博士专项课题(SJXTBS2120,SJXTBZ2114);江苏省教育科学“十四五”规划课题(C-c/2021/03/24,B/2021/03/17);江苏省高等教育教改研究立项课题(2021JSJG467,2021JSJG168)。

摘　　要：以芳甲酰甲醛、芳基脒和乙酸酐为起始原料,在80℃的醋酸溶剂中,经分子内环化/分子间亲电加成反应,合成了一系列2,3,5-三取代咪唑衍生物,优化收率在63%~82%之间.所有产物的结构均经核磁共振氢谱、红外光谱和高分辨率质谱证实,并且化合物4c的结构得到了X-单晶衍射的确认.By using arylglyoxal monohydrate,aromatic amidine,and acetic anhydride as starting materials,a series of 2,3,5-trisubstituted imidazole derivatives were synthesized via intramolecular cyclization/intermolecular electrophilic addition reaction in acetic acid solvent at 80℃.The optimized yields ranged from 63%to 82%.The structures of all products were confirmed by ^(1)H NMR,IR,and HRMS.Additionally,the structure of compound 4c was also confirmed by X-ray single crystal diffraction.

关 键 词：芳甲酰甲醛 芳基脒 咪唑 

分 类 号：O626[理学—有机化学]