A型肉毒毒素在妊娠期的应用和安全性研究进展  

Research progress on the application and safety of botulinum toxin type A during pregnancy

作　　者：刘雅楠 程虹[1] LIU Yanan;CHENG Hong(Department of Pharmacy,Zhongnan Hospital of Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院药学部,武汉430071

出　　处：《药物流行病学杂志》2025年第2期216-223,共8页Chinese Journal of Pharmacoepidemiology

基　　金：中国毒理学会临床毒理专项(CST2020CT302)。

摘　　要：A型肉毒毒素已广泛用于疾病治疗与美容塑型,其中育龄女性是使用A型肉毒毒素的重点人群,关于该药物的妊娠期用药咨询逐渐增多,但该药物在妊娠期的应用和安全性研究国内报道较少。本文综述国内外妊娠期和孕前使用A型肉毒毒素的病例报道和临床研究,以及妊娠期肉毒毒素中毒的妊娠结局,讨论A型肉毒毒素在妊娠期使用的安全性和局限性。研究显示,妊娠期患者使用A型肉毒毒素可缓解症状,效果较好,可使患者避免妊娠期手术或使用安全性较低的药物。妊娠期暴露于A型肉毒毒素并未增加胎儿的出生缺陷发生率。肉毒毒素中毒的妊娠期患者应及时给予肉毒杆菌抗毒素治疗。基于目前的研究数据建议,在充分告知患者用药风险后,A型肉毒毒素可作为治疗药物在妊娠期使用。Botulinum toxin type A has been widely used in disease treatment and cosmetic shaping.Women of childbearing age are the key population using botulinum toxin type A.Consultations about this drug are gradually increasing,but domestic reports on the application and safety during pregnancy are relatively rare.This study reviews the case reports of using botulinum toxin type A during pregnancy and before pregnancy,as well as pregnancy outcomes of botulinum toxin poisoning during pregnancy,discussing the safety and limitations of using botulinum toxin type A during pregnancy.The study showed when used in pregnancy at therapeutic doses,botulinum toxin type A has good effects on patients and can alleriate the patients'symptoms.Patients can avoid surgery or using drugs with lower safety during pregnancy.Exposure to botulinum toxin type A during pregnancy does not increase the incidence of fetal defects.Botulinum antitoxin should be given promptly to pregnant women with botulinum toxin type A poisoning.According to the current research data,it is suggested that botulinum toxin type A can be used as a therapeutic agent during pregnancy after fully informing patients of the risks of medication.

关 键 词：A型肉毒毒素 妊娠期安全性 出生缺陷 肉毒杆菌抗毒素 

分 类 号：R979.9[医药卫生—药品]