升血小板胶囊致缺血性肠病1例分析  

A case report of ischemic bowel disease caused by Shengxuexiaoban capsules

作　　者：许翠林 李彬彬 胡静[4] 胡乃中[4] 汪燕燕[2] XU Cuilin;LI Binbin;HU Jing;HU Naizhong;WANG Yanyan(Department of Pharmacy,Bozhou Hospital of Traditional Chinese Medicine,Bozhou 236800,Anhui Province,China;Department of Pharmacy,the First Affiliated Hospital of Anhui Medical University,Hefei 230000,China;Department of Pharmacy,the First People's Hospital of Yulin,Yulin 537000,Guangxi Zhuang Autonomous Region,China;Department of Gastroenterology,the First Affiliated Hospital of Anhui Medical University,Hefei 230000,China)

机构地区：[1]亳州市中医院药学部,安徽亳州236800 [2]安徽医科大学第一附属医院药剂科,合肥230000 [3]玉林市第一人民医院药学部,广西玉林537000 [4]安徽医科大学第一附属医院消化内科,合肥230000

出　　处：《药物流行病学杂志》2025年第2期236-240,共5页Chinese Journal of Pharmacoepidemiology

基　　金：安徽省自然科学基金青年项目(1508085QH166);安徽医科大学校科研基金项目(2022xkj154)。

摘　　要：1例76岁男性肺癌患者因化疗致血小板降低,口服升血小板胶囊3 d后出现左下腹痉挛性疼痛,解血便4次,血常规提示:白细胞计数11.54×10^(9)·L^(-1),嗜中性粒细胞百分比82.4%,血小板计数93×10^(9)·L^(-1),C-反应蛋白23.50 mg·L^(-1);粪便隐血阳性,病理检查提示直肠黏膜缺血样改变,诊断为缺血性肠病。经补液、抗感染等治疗后,患者腹痛消失,大便转黄。采用Naranjo's评估量表对患者缺血性肠病不良反应与升血小板胶囊的关联性进行分析评价,结果为很可能有关。本文通过该病例全面分析升血小板胶囊致缺血性肠病的临床特点和药物治疗过程,旨在为临床安全用药提供参考。A 76-year-old male patient with lung cancer developed thrombocytopenia due to chemotherapy.Three days after taking the Shengxuexiaoban capsules orally,he experienced abdominal pain and bloody stool and was admitted to the hospital.The blood test showed white blood cell count of 11.54×10^(9)·L^(-1),neutrophil percentage of 82.4%,platelet count of 93×10^(9)·L^(-1),and C-reactive protein level of 23.50 mg·L^(-1).Fecal occult blood test positive,and pathology indicatesd ischemic-like changes in the rectal mucosa.The patient was diagnosed with ischemic bowel disease.After treatment with fluid replacement and anti-infection,the patient's abdominal pain disappeared and his stool turned yellow.The Naranjo’s Assessment Scale was used to evaluate the association between adverse effects of ischemic bowel disease and Shengxuexiaoban capsules,and the result was very likely related.This article analysed the clinical characteristics and drug treatment process of ischemic bowel disease caused by Shengxuexiaoban capsule through this case,aiming to provide references for the safe use of drugs in the clinically.

关 键 词：升血小板胶囊 缺血性肠病 药品不良反应 

分 类 号：R286[医药卫生—中药学]