2001—2023年干细胞治疗膝关节骨关节炎研究的文献计量学分析  

Bibliometric analysis of research on stem cell therapy for knee osteoarthritis from 2001 to 2023

作　　者：李智卓 杜瑞 徐兴全[1,2] 蒋青 LI Zhizhuo;DU Rui;XU Xingquan;JIANG Qing(Division of Sports Medicine and Adult Reconstructive Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China;Branch of National Clinical Research Center for Orthopedics,Sports Medicine and Rehabilitation,Nanjing 210008,China;Division of Sports Medicine and Adult Reconstructive Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Xuzhou Medical University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院骨科/运动医学与成人重建外科,南京210008 [2]国家骨科与运动康复临床医学研究中心分中心,南京210008 [3]徐州医科大学南京鼓楼临床学院骨科/运动医学与成人重建外科,南京210008

出　　处：《医学新知》2025年第2期183-190,共8页New Medicine

基　　金：国家自然科学基金重大研究计划(92368201);国家自然科学基金重大项目(81991514)。

摘　　要：目的分析干细胞治疗膝关节骨关节炎(knee osteoarthritis,KOA)研究现状、热点以及前沿。方法检索Web of Science核心合集中关于干细胞治疗KOA的文献,检索时限为2001—2023年,通过CiteSpace软件对文献载文量、引用频次、作者分布、期刊分布、文献发表领域、关键词频次及聚类等进行可视化分析。结果共纳入2420篇文献,干细胞治疗KOA的发文量及被引次数逐年增多,2022年达到顶峰。美国、中国和日本的发文量占总量的50%左右。发文量最多的机构来自中国浙江大学。主要发文作者包括Sekiya Ichiro(29篇)、Koga Hideyuki(24篇)、Muneta Takeshi(16篇)等。主要发文期刊包括Osteoarthritis and Cartilage(103篇)、International Journal of Molecular Sciences(84篇)、American Journal of Sports Medicine(74篇)等。人关节软骨细胞、膝骨关节炎、软骨修复、损伤、细胞外囊泡是5个主要的关键词聚类群。突现词由十年前的前交叉韧带、自体软骨细胞移植变化为近年来的细胞外囊泡和外泌体。结论干细胞治疗KOA的研究热度持续上升,近年来细胞外囊泡和外泌体等分子机制相关研究方向成为该领域的新兴焦点,未来需进一步关注干细胞在软骨修复中的临床应用以及分子机制研究。Objective To analyze the current status,hot topics,and frontiers of stem cell therapy research for knee osteoarthritis(KOA).Methods English literatures on stem cell therapy for KOA published from 2001 to 2023 were retrieved from the Web of Science Core Collection.CiteSpace software was employed to visually analyze publication volume,citation frequency,author distribution,journal of publication,field distribution,keyword frequency,and clustering.Results A total of 2,420 articles were included in the analysis.The number of publications and citations related to stem cell therapy for KOA had shown a consistent annual increase,peaking in 2022.The publications of the United States,China,and Japan accounted for approximately 50%of the total publications.Zhejiang University in China was the institution with the highest publication volume.The most prolific authors included Sekiya Ichiro(29 articles),Koga Hideyuki(24 articles),and Muneta Takeshi(16 articles).The top three journals were Osteoarthritis and Cartilage(103 articles),International Journal of Molecular Sciences(84 articles),and American Journal of Sports Medicine(74 articles).The five main keyword clusters identified were human articular chondrocyte,KOA,cartilage repair,injury,and extracellular vesicles.The emergence words has changed from anterior cruciate ligament and autologous chondrocyte implantation ten years ago to extracellular vesicles and exosomes in recent years.Conclusion The research on stem cell therapy for KOA continues to rise,and in recent years,molecular mechanisms related to extracellular vesicles and exosomes have become emerging focuses in this field.In the future,further attention needs to be paid to the clinical application of stem cells in cartilage repair and molecular mechanism research.

关 键 词：干细胞 膝关节骨关节炎 文献计量 研究热点 CITESPACE 可视化分析 

分 类 号：R684.3[医药卫生—骨科学]