超脉冲CO_(2)点阵激光联合微针射频靶向治疗面部痤疮凹陷性瘢痕的效果研究  

Effect of ultrapulse CO_(2)dot matrix laser combined with microneedle radiofrequency in the treatment of depressed scar of facial acne

作　　者：张英午 徐保来[2] ZHANG Ying-wu;XU Bao-lai(Department of Dermatology,Xixia County People's Hospital,Xixia 474500,Henan,CHINA;Department of Dermatology,Nanyang Central Hospital,Nanyang 473005,Henan,CHINA)

机构地区：[1]西峡县人民医院皮肤科,河南西峡474500 [2]南阳市中心医院皮肤科,河南南阳473005

出　　处：《海南医学》2025年第4期508-512,共5页Hainan Medical Journal

基　　金：河南省医学科技攻关计划项目(编号:201702354)。

摘　　要：目的探讨超脉冲二氧化碳(CO_(2))点阵激光联合微针射频靶向治疗面部痤疮凹陷性瘢痕的效果。方法选择2015年12月至2023年3月西峡县人民医院收治的186例面部痤疮凹陷性瘢痕患者作为研究对象,按随机数表法分为观察组和对照组各93例。对照组患者采用超脉冲CO_(2)点阵激光治疗,观察组患者在对照组治疗的基础上联合微针射频靶向治疗,每3个月为一个疗程,共治疗3个疗程。治疗3个疗程后,比较两组患者的临床疗效;治疗前及治疗3个疗程后,比较两组患者的痤疮瘢痕权重评分表(ECCA)、温哥华瘢痕评定量表(VSS)评分、皮肤经皮水分丢失(TEWL)值、角质层含水量、痤疮特异性生活量表(Acen-QoL)评分(包括情感功能、自我感知、社会功能评分);比较两组患者在治疗期间的不良反应发生情况。结果治疗3个疗程后,观察组患者的临床疗效总有效率为94.62%,明显高于对照组的83.87%,差异有统计学意义(P<0.05)。治疗前,两组患者的ECCA评分、VSS评分比较差异均无统计学意义(P>0.05);治疗3个疗程后,两组患者的ECCA评分、VSS评分均降低,且观察组患者的ECCA评分、VSS评分分别为(24.04±3.18)分、(5.34±1.29)分,明显低于对照组的(41.35±4.93)分、(6.20±1.33)分,差异均有统计学意义(P<0.05)。治疗前,两组患者的TEWL值、角质层含水量比较差异均无统计学意义(P>0.05);治疗后,两组患者的TEWL值均降低,角质层含水量均升高,且观察组患者的TEWL值为(17.41±2.06)g/(h·m^(2)),明显低于对照组的(23.56±2.93)g/(h·m^(2)),角质层含水量为(31.06±2.68)%,明显高于对照组的(25.91±3.12)%,差异均有统计学意义(P<0.05)。治疗前,两组患者的Acen-QoL评分比较差异无统计学意义(P>0.05);治疗后,两组患者Acen-QoL评分中的情感功能、自我感知、社会功能评分均升高,且观察组患者Acen-QoL评分中的情感功能、自我感知、社会功能评分分别为(26.21±1.86)分、Objective To investigate the effect of ultrapulse carbon dioxide(CO_(2))dot matrix laser combined with microneedle radiofrequency in the treatment of depressed scar of facial acne.Methods A total of 186 patients with facial acne and depressed scars admitted to Xixia County People's Hospital from December 2015 to March 2023 were selected as the research subjects and randomly divided into an observation group and a control group using a random number table method,with 93 patients in each group.Patients in the control group were treated with ultrapulse CO_(2)dot matrix laser,while those in the observation group received microneedle radiofrequency on the basis of the treatment in the control group,with every three months as one course of treatment,for a total of three courses.After 3 courses of treatment,the clinical efficacy was compared between the two groups of patients;before treatment and after 3 courses of treatment,the acne scar Weight Rating Scale(ECCA)and Vancouver Scar Rating Scale(VSS)scores between the two groups of patients were compared,as well as the transepidermal water loss(TEWL)value,water content of the stratum corneum,the Acne-Specific Quality of Life Questionnaire(Acne-QoL)scores(including emotional function,self-perception,and social function scores);the incidence of adverse reactions during treatment between the two groups was also compared.Results After 3 courses of treatment,the total effective rate of clinical efficacy in the observation group was 94.62%,significantly higher than the control group's 83.87%(P<0.05).Before treatment,there was no statistically significant difference in ECCA scores and VSS scores between the two groups of patients(P>0.05);after 3 courses of treatment,the ECCA score and VSS score of both groups of patients decreased,and the ECCA score and VSS score of the observation group were(24.04±3.18)points and(5.34±1.29)points,respectively,which were significantly lower than(41.35±4.93)points and(6.20±1.33)points of the control group,with statistically significant diffe

关 键 词：痤疮 凹陷性瘢痕 超脉冲二氧化碳点阵激光 微针 疗效 生活质量 不良反应 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]