单纯肥胖儿童miR-122、SIRT4、Omentin-1与肥胖程度、胰岛素抵抗的相关性研究  

Correlation between miR-122,SIRT4,Omentin-1 and obesity severity,insulin resistance in children with simple obesity

作　　者：陈云秋 刘静[1] 杨红[1] CHEN Yun-qiu;LIU Jing;YANG Hong(Children's Health Management Center,Nanyang Central Hospital,Nanyang 473000,Henan,CHINA)

机构地区：[1]南阳市中心医院儿童健康管理中心,河南南阳473000

出　　处：《海南医学》2025年第4期522-527,共6页Hainan Medical Journal

基　　金：2022年河南省医学科技攻关联合共建项目(编号:LHGJ20223049)。

摘　　要：目的探讨单纯肥胖儿童血清微小RNA-122(miR-122)、人去乙酰化酶4(SIRT4)、网膜素-1(Omentin^(-1))水平与肥胖程度、胰岛素抵抗(IR)的相关性。方法按照2∶1的比例选取2022年6月至2024年6月南阳市中心医院收治的204例单纯肥胖儿童(肥胖组)和生长发育门诊102例体检非肥胖儿童(对照组)纳入研究。比较两组儿童的血清miR-122、SIRT4、Omentin^(-1)水平与稳态模型胰岛素抵抗指数(HOMA-IR);比较不同肥胖程度患儿的基线资料及血清miR-122、SIRT4、Omentin^(-1)水平;采用多分类Logistic回归方程分析miR-122、SIRT4、Omentin^(-1)与肥胖程度的相关性,并建立多分类Logistic回归模型,分析该模型评估肥胖程度的准确性;采用Pearson相关性分析肥胖组miR-122、SIRT4、Omentin^(-1)与HOMA-IR相关性。结果肥胖组儿童的血清miR-122水平、HOMA-IR分别为1.19±0.39、2.04±0.50,明显高于对照组的0.78±0.20、1.59±0.44,SIRT4、Omentin^(-1)水平分别为(0.95±0.31)mmol/L、(221.95±79.86)pg/mL,明显低于对照组的(1.34±0.27)mmol/L、(318.76±88.54)pg/mL,差异均有统计学意义(P<0.05);重度肥胖患儿的血清miR-122水平、HOMA-IR分别为1.80±0.31、2.31±0.37,明显高于中度肥胖患儿的1.27±0.36、2.10±0.43和轻度肥胖患儿的0.80±0.25、1.82±0.39,SIRT4、Omentin^(-1)水平分别为(0.59±0.18)mmol/L、(194.76±36.55)pg/mL,明显低于中度肥胖患儿的(0.90±0.27)mmol/L、(219.35±30.78)pg/mL和轻度肥胖患儿的(1.20±0.39)mmol/L、(238.54±34.71)pg/mL,差异均有统计学意义(P<0.05);以轻度肥胖为参考项,miR-122、SIRT4、Omentin^(-1)作为自变量,建立多分类Logistic回归模型,ln(重度肥胖/轻度肥胖)=1.669+0.566×miR-122-0.685×SIRT4-0.534×Omentin^(-1),ln(中度肥胖/轻度肥胖)=0.144+0.424×miR-122-0.839×SIRT4-0.738×Omentin^(-1),且miR-122、SIRT4、Omentin^(-1)均与肥胖程度呈显著相关性(P<0.05);多分类Logistic回归模型解释重度、中度、轻度肥胖的准确率分别为91.89%、94Objective To investigate the correlation between the levels of serum microRNA-122(miR-122),human sirtuin 4(SIRT4),and omentin-1(Omentin^(-1))in children with simple obesity and their obesity severity and insulin resistance(IR).Methods According to 2:1,204 children with simple obesity admitted to Nanyang Central Hospital from June 2022 to June 2024(obese group)and 102 non-obese children undergoing physical examination in the Growth and Development Clinic(control group)were selected for inclusion in the study.The levels of serum miR-122,SIRT4,and Omentin^(-1),as well as the Homeostatic Model Assessment of Insulin Resistance(HOMA-IR)index,were compared between the two groups of children.The baseline data and serum levels of miR-122,SIRT4,and Omentin^(-1)were com-pared among children with different degrees of obesity.Multiclass logistic regression equations were used to analyze the correlation between miR-122,SIRT4,Omentin^(-1)and the obesity severity,and a multiclass logistic regression model was established to analyze the accuracy of this model in assessing the obesity degree.Pearson correlation analysis was used to analyze the correlation between miR-122,SIRT4,Omentin^(-1)and HOMA-IR in the obese group.Results The serum levels of miR-122 and HOMA-IR in obese group were 1.19±0.39 and 2.04±0.50,respectively,which were significantly higher than 0.78±0.20 and 1.59±0.44 in the control group;the levels of SIRT4 and Omentin^(-1)were(0.95±0.31)mmol/L and(221.95±79.86)pg/mL,respectively,which were significantly lower than(1.34±0.27)mmol/L and(318.76±88.54)pg/mL in the control group;the differences were statistically significant(P<0.05).The serum levels of miR-122 and HOMA-IR in severely obese children were 1.80±0.31 and 2.31±0.37,respectively,which were significantly higher than 1.27±0.36 and 2.10±0.43 in moderately obese children and 0.80±0.25 and 1.82±0.39 in mildly obese children;the levels of SIRT4 and Omentin^(-1)were(0.59±0.18)mmol/L and(194.76±36.55)pg/mL,respectively,which were significantly lower t

关 键 词：儿童 单纯肥胖 微小RNA-122 人去乙酰化酶4 网膜素-1 肥胖程度 胰岛素抵抗 相关性 

分 类 号：R725.8[医药卫生—儿科]