Traditional Chinese medicine for chronic atrophic gastritis:Efficacy,mechanisms and targets  

作　　者：Li Wang Yan-Jie Lian Jin-Sheng Dong Ming-Kun Liu Hong-Liang Liu Zheng-Min Cao Qing-Nan Wang Wen-Liang Lyu Yu-Ning Bai 

机构地区：[1]Department of Gastroenterology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China [2]Division of Cardiovascular,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China [3]Department of Infectious Diseases,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China [4]Department of Dermatology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China

出　　处：《World Journal of Gastroenterology》2025年第9期9-29,共21页世界胃肠病学杂志(英文)

基　　金：Supported by the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences,No.CI2021A00806;High Level Chinese Medical Hospital Promotion Project,No.HLCMHPP2023086;the Fundamental Research Funds for the Central Public Welfare Research Institutes,No.ZZ17-XRZ-041.

摘　　要：Chronic atrophic gastritis(CAG)is an important stage of precancerous lesions of gastric cancer.Effective treatment and regulation of CAG are essential to prevent its progression to malignancy.Traditional Chinese medicine(TCM)has shown multi-targeted efficacy in CAG treatment,with advantages in enhancing gastric mucosal barrier defense,improving microcirculation,modulating inflammatory and immune responses,and promoting lesion healing,etc.Clinical studies and meta-analyses indicate that TCM provides significant benefits,with specific Chinese herbal compounds and monomers demonstrating protective effects on the gastric mucosa through mechanisms including anti-inflammation,antioxidation,and regulation of cellular proliferation and apoptosis,etc.Finally,it is pointed out that the efficacy of TCM in the treatment of CAG requires standardized research and unified standards,and constantly clarifies and improves the evaluation criteria of each dimension of gastric mucosal barrier function.

关 键 词：Traditional Chinese medicine Gastric mucosal barrier Chronic atrophic gastritis Therapeutic efficacy Treating target 

分 类 号：R57[医药卫生—消化系统]