Metabolic dysfunction-associated steatotic liver disease and type 2 diabetes:A dual threat to cardiac dysfunction progression  

作　　者：Wei Wang Charlie Cooper 

机构地区：[1]Chronic Disease and Health Management Research Center,Geriatric Hospital of Nanjing Medical University,Nanjing 210024,Jiangsu Province,China

出　　处：《World Journal of Cardiology》2025年第1期118-120,共3页世界心脏病学杂志(英文)

摘　　要：Metabolic dysfunction-associated steatotic liver disease(MASLD),particularly in patients with type 2 diabetes mellitus(T2DM),is increasingly recognized as a multi-system disease that affects both hepatic and cardiovascular health.This study explores the association between MASLD-related liver fibrosis and cardiac dysfunction,focusing on how liver fibrosis contributes to cardiac remodeling and dysfunction.Cernea et al’s research highlights the strong correlation between liver fibrosis and changes in left ventricular mass,left atrial dimensions,and systolic and diastolic function in diabetic patients.Notably,the study suggests a protective role of sex-hormone binding protein against cardiac remodeling.These findings underline the importance of early detection of liver fibrosis using noninvasive markers like fibrosis-4 index and nonalcoholic fatty liver disease fibrosis scores,which may offer dual protection for both liver and heart health in T2DM patients.Moreover,this study calls for further research into the shared pathogenic mechanisms,including inflammation and fibrosis pathways,between the liver and heart.It advocates for the integration of liver fibrosis screening into cardiovascular risk management,urging clinicians to adopt a more holistic approach in treating patients with MASLD and T2DM.The research has broad implications for preventing cardiovascular complications and improving outcomes in this highrisk population.

关 键 词：Metabolic dysfunction-associated steatotic liver disease Type 2 diabetes Cardiac dysfunction Left ventricular mass Sex-hormone binding protein Fibrosis-4 index scores 

分 类 号：R57[医药卫生—消化系统]