Risk stratification for future cardiac arrest after COVID-19 vaccination  

作　　者：Peter A McCullough Nicolas Hulscher 

机构地区：[1]Department of Cardiology,McCullough Foundation,Dallas,TX 75206,United States [2]Department of Epidemiology,McCullough Foundation,Dallas,TX 75206,United States

出　　处：《World Journal of Cardiology》2025年第2期22-28,共7页世界心脏病学杂志(英文)

摘　　要：Unheralded cardiac arrest among previously healthy young people without antecedent illness,months or years after coronavirus disease 2019(COVID-19)vaccination,highlights the urgent need for risk stratification.The most likely underlying pathophysiology is subclinical myopericarditis and reentrant ventri-cular tachycardia or spontaneous ventricular fibrillation that is commonly preci-pitated after a surge in catecholamines during exercise or the waking hours of terminal sleep.Small patches of inflammation and/or edema can be missed on cardiac imaging and autopsy,and the heart can appear grossly normal.This paper reviews evidence linking COVID-19 vaccines to cardiac arrest where unfortu-nately the majority of victims have had no antecedent clinical evaluation.We propose a comprehensive strategy for evaluating cardiovascular risk post-vaccination,incorporating detailed patient history,antibody testing,and cardiac diagnostics in the best attempt to detect abnormalities before sudden cardiac death.This approach aims to identify individuals at higher risk of cardiac events after COVID-19 vaccination and guide appropriate clinical management.It is prudent for each primary care physician to have a pre-established plan when addressing this issue in their practice.

关 键 词：COVID-19 mRNA vaccines MYOCARDITIS Cardiac arrest Risk stratification Cardiovascular safety 

分 类 号：R186[医药卫生—流行病学]