Updates in breathomics behavior in ischemic heart disease and heart failure,mass-spectrometry  

作　　者：Basheer Abdualah Marzoog Peter Chomakhidze Daria Gognieva Alena Yurievna Parunova Snezhana Nikolaevna Demchuk Artemiy Silantyev Natalia Kuznetsova Anastasia Kostikova Dmitrii Podgalo Evgeny Nagornov Aida Gadzhiakhmedova Philipp Kopylov 

机构地区：[1]Department of Cardiology,Sechenov University,Moscow 119991,Moskva,Russia [2]Undergraduate Student,National Research Ogarev Mordovia State University,Saransk 430005,Russia [3]Undergraduate Student,Omsk State Medical University,Omsk 644099,Russia [4]Undergraduate Student,Sechenov University,Moscow 119991,Moskva,Russia

出　　处：《World Journal of Cardiology》2025年第2期85-92,共8页世界心脏病学杂志(英文)

基　　金：Supported by the Government Assignment to Philipp Kopylov,No.1023022600020-6;Russian Science Foundation Grant to Philipp Kopylov,No.24-15-00549;the Ministry of Science and Higher Education of the Russian Federation within the Framework of State Support for the Creation and Development of World-Class Research Center to Basheer Marzoog and Peter Chomakhidze,No.075-15-2022-304.

摘　　要：BACKGROUND Cardiovascular disease(CVD)and associated sequalae remain the leading cause of disability worldwide.Ischemic heart disease(IHD)and heart failure are the most common etiologies of morbidity and mortality worldwide.This is due to the poor diagnostic and management methods for heart failure and IHD.Early detection of related risk factors through modern strategies is underestimated and requires further research.AIM To interpret data from the published literature on volatile organic compounds(VOC),including all the methods used to analyze exhaled breath in patients with IHD and heart failure.METHODS Searches for specific keywords were performed on Scopus and PubMed.A total of 20 studies were identified in breath analysis and IHD and heart failure.The study is registered in PROSPERO(Registration No.CRD42023470556).RESULTS Considering the articles found,more research is required to gain a full understanding of the role of VOCs in IHD and heart failure.However,the existing literature demonstrates that cardiac metabolic changes can be expressed in exhaled air.The number of papers found is extremely low,making interpretation extremely difficult.CONCLUSION Exhaled breath analysis can be a novel biomarker for the diagnosis and prevention of heart failure and IHD.Exhaled breath analysis can be used as a mirror to reflect the metabolic changes related to IHD and heart failure.

关 键 词：Systemic review Mass spectrometry Ischemic heart disease ARRYTHMIA Angina pectoris 

分 类 号：R54[医药卫生—心血管疾病]