左卡尼汀联合胺碘酮治疗老年心力衰竭合并心房颤动患者的效果  

Effects of levocarnitine combined with Amiodarone in treatment of elderly patients with heart failure complicated with atrial fibrillation

作　　者：赵灿 ZHAO Can(Department of Pharmacy of Minquan County People’s Hospital,Shangqiu 476800 Henan,China)

机构地区：[1]民权县人民医院药学部,河南商丘476800

出　　处：《中国民康医学》2025年第4期34-36,40,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察左卡尼汀联合胺碘酮治疗老年心力衰竭合并心房颤动患者的效果。方法:选取2022年10月至2023年10月该院收治的90例老年心力衰竭合并心房颤动患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各45例。两组均进行基础治疗,在此基础上,对照组予以胺碘酮治疗,研究组在对照组基础上联合左卡尼汀治疗,两组均治疗4周。比较两组临床疗效,治疗前后心功能指标[静息心率、运动心率、左心室射血分数(LVEF)]、心肌损伤指标[N-末端脑钠肽前体(NT-proBNP)、可溶性致癌抑制因子2(sST2)]、血管内皮功能指标[内皮素-1(ET-1)、一氧化氮(NO)]水平,以及不良反应发生率。结果:研究组治疗总有效率为88.89%(40/45),高于对照组的71.11%(32/45),差异有统计学意义(P<0.05);治疗后,两组静息心率、运动心率均低于治疗前,且研究组低于对照组,两组LVEF水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组NT-proBNP、sST2水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组ET-1水平均低于治疗前,且研究组低于对照组,两组NO水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:左卡尼汀联合胺碘酮治疗老年心力衰竭合并心房颤动患者可提高治疗总有效率,改善心功能指标和血管内皮功能指标水平,降低心肌损伤指标水平,效果优于单纯胺碘酮治疗。Objective:To observe effects of levocarnitine combined with Amiodarone in treatment of elderly patients with heart failure and atrial fibrillation.Methods:A prospective study was conducted on 90 elderly patients with heart failure and atrial fibrillation admitted to this hospital from October 2022 to October 2023.According to the random number table method,they were divided into study group and control group,45 cases in each group.Both groups received basic treatment.On this basis,the control group was treated with Amiodarone,while the study group was treated with Levocarnitine on the basis of that of the control group.Both groups were treated for 4 weeks.The clinical efficacy,the levels of cardiac function indexes[resting heart rate,exercise heart rate,left ventricular ejection fraction(LVEF)],myocardial injury indexes[N-terminal pro-brain natriuretic peptide(NT-proBNP),soluble tumor suppressor 2(sST2)]and vascular endothelial function indexes[endothelin-1(ET-1),nitric oxide(NO)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 88.89%(40/45),which was higher than 71.11%(32/45)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the resting heart rate and exercise heart rate of the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the LVEF levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the differences were statistically significant(P<0.05).After the treatment,the levels of NT-proBNP and sST2 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of ET-1 in the two groups were lower than those before the treatment,and that in the stu

关 键 词：左卡尼汀 胺碘酮 老年 心力衰竭 心房颤动 心功能 血管内皮功能 心肌损伤 

分 类 号：R541.75[医药卫生—心血管疾病]