转移因子口服溶液联合盐酸氨溴索治疗肺炎支原体肺炎患儿的效果  

Effects of transfer factor oral solution combined with Ambroxol hydrochloride in treatment of children with mycoplasma pneumoniae pneumonia

作　　者：邰银锋 扈晓轩 梁呈祥 TAI Yinfeng;HU Xiaoxuan;LIANG Chengxiang(Department of Pediatrics of Xinyang People’s Hospital,Xinyang 464000 Henan,China)

机构地区：[1]信阳市人民医院儿科,河南信阳464000

出　　处：《中国民康医学》2025年第4期44-46,50,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察转移因子口服溶液联合盐酸氨溴索治疗肺炎支原体肺炎(MPP)患儿的效果。方法:回顾性分析2022年3月至2023年10月该院收治的76例MPP患儿的临床资料,按照治疗方法不同将其分为对照组与观察组各38例。对照组采用盐酸氨溴索治疗,观察组在对照组基础上联合转移因子口服溶液治疗。比较两组临床疗效,临床症状(肺部啰音、咳嗽、气促、发热)消失时间,治疗前后T细胞亚群指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、血清学因子[血清粒细胞-巨噬细胞集落刺激因子(GM-CSF)、白细胞介素-6(IL-6)、半胱氨酰白三烯(CysLTs)]水平,以及治疗期间不良反应发生率。结果:观察组治疗总有效率为92.11%(35/38),高于对照组的73.68%(28/38),差异有统计学意义(P<0.05);观察组发热、气促、咳嗽、肺部啰音消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、GM-CSF、CysLTs水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:转移因子口服溶液联合盐酸氨溴索治疗MPP患儿可提高治疗总有效率和T细胞亚群指标水平,缩短临床症状消失时间,以及降低血清学因子水平,效果优于单纯盐酸氨溴索治疗。Objective:To observe effects of transfer factor oral solution combined with Ambroxol hydrochloride in treatment of children with mycoplasma pneumoniae pneumonia(MPP).Methods:The clinical data of 76 children with MPP admitted to this hospital from March 2022 to October 2023 were retrospectively analyzed.According to the different treatment methods,they were divided into control group and observation group,38 cases in each group.The control group was treated with Ambroxol hydrochloride,while the observation group was treated with transfer factor oral solution on the basis of that of the control group.The clinical efficacy,the disappearance time of clinical symptoms(pulmonary rales,cough,shortness of breath,fever),the levels of T cell subsets(CD3^(+),CD4^(+),CD4^(+)/CD8^(+))and serological factors[serum granulocyte-macrophage colony stimulating factor(GM-CSF),interleukin-6(IL-6),cysteinyl leukotrienes(CysLTs)]before and after the treatment,and the incidence of adverse reactions during treatment were compared between the two groups.Results:The total effective rate of the observation group was 92.11%(35/38),which was higher than 73.68%(28/38)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of fever,shortness of breath,cough and pulmonary rales in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,GM-CSF and CysLTs in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the

关 键 词：转移因子口服溶液 盐酸氨溴索 肺炎支原体肺炎 儿童 不良反应 T细胞亚群 临床症状 

分 类 号：R725.6[医药卫生—儿科]