机构地区:[1]光山县人民医院皮肤性病科,河南信阳465450
出 处:《中国民康医学》2025年第4期61-63,67,共4页Medical Journal of Chinese People’s Health
摘 要:目的:观察复方氨肽素片联合阿维A胶囊治疗寻常型银屑病(PV)患者的效果。方法:回顾性分析2021年7月至2023年9月该院收治的82例PV患者的临床资料,根据治疗方法不同将其分为对照组(n=41)和观察组(n=41)。对照组予以阿维A胶囊治疗,观察组在对照组基础上联合复方氨肽素片治疗,比较两组临床疗效,治疗前后银屑病皮损面积和严重程度指数(PASI)评分、皮肤病生活质量指数(DLQI)评分、皮肤屏障功能指标(皮脂含量、角质层含水量、pH值)水平、T细胞亚群指标水平,以及治疗期间不良反应发生率。结果:观察组治疗总有效率为90.24%(37/41),高于对照组的73.17%(30/41),差异有统计学意义(P<0.05);治疗后,观察组PASI和DLQI评分均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组皮脂含量、角质层含水量均高于对照组,pH值低于对照组,差异有统计学意义(P<0.05);治疗后,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:复方氨肽素片联合阿维A胶囊治疗PV患者可提高治疗总有效率和T细胞亚群指标水平,改善皮肤屏障功能指标水平,降低PASI和DLQI评分,效果优于单纯阿维A胶囊治疗。Objective:To observe effects of Compound amino-polyprptide tablets combined with Acitretin capsules in treatment of patients with psoriasis vulgaris(PV).Methods:The clinical data of 82 patients with PV admitted to this hospital from July 2021 to September 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group(n=41)and observation group(n=41).The control group was treated with Acitretin capsules,while the observation group was treated with Compound amino-polyprptide tablets on the basis of that of the control group.The clinical efficacy,the psoriasis area and severity index(PASI)score,the dermatology quality of life index(DLQI)score,the skin barrier function index(sebum content,stratum corneum water content,pH value)levels,and the T cell subset index levels before and after the treatment,and the incidence of adverse reactions during treatment were compared between the two groups.Results:The total effective rate of the observation group was 90.24%(37/41),which was higher than 73.17%(30/41)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the PASI and DLQI scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the sebum content and the stratum corneum water content in the observation group were higher than those in the control group,the pH value was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compound amino-polyprptide tablets combined with Acitretin capsules in the treatment of the PV patients can improve the total effective rate of treatment and t
关 键 词:复方氨肽素片 阿维A胶囊 寻常型银屑病 T细胞亚群 皮肤屏障功能
分 类 号:R758.63[医药卫生—皮肤病学与性病学]
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