孕早期HbA1c、HOMA-IR水平联合检测对妊娠期糖尿病的预测价值  

Predictive value of combined detection of HbA1c and HOMA-IR levels in early pregnancy for gestational diabetes mellitus

作　　者：王静花 肖雪娟 WANG Jinghua;XIAO Xuejuan(Department of Clinical Laboratory of the Third People’s Hospital of Zhengzhou,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州市第三人民医院检验科,河南郑州450000

出　　处：《中国民康医学》2025年第4期132-134,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析孕早期糖化血红蛋白(HbA1c)、稳态模型评估胰岛素抵抗指数(HOMA-IR)水平联合检测对妊娠期糖尿病(GDM)的预测价值。方法:回顾性分析2021年5月至2024年2月该院收治的94例GDM患者的临床资料,设为研究组。回顾性分析同期于该院行常规产检的94名健康孕妇的临床资料,设为对照组。比较两组孕早期HbA1c、HOMA-IR水平,绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),分析孕早期HbA1c、HOMA-IR水平联合检测对GDM的预测价值。结果:研究组HbA1c、HOMA-IR水平均高于对照组,差异有统计学意义(P<0.05);ROC曲线分析结果显示,孕早期HbA1c、HOMA-IR水平单项及联合检测预测GDM的AUC分别为0.716、0.775、0.848,其中联合检测的AUC最高。结论:孕早期HbA1c、HOMA-IR水平联合检测对GDM的预测价值高于各指标单项检测。Objective:To analyze predictive value of combined detection of glycosylated hemoglobin(HbA1c)and homeostasis model assessment of insulin resistance(HOMA-IR)in early pregnancy for gestational diabetes mellitus(GDM).Methods:The clinical data of 94 patients with GDM admitted to this hospital from May 2021 to February 2024 were retrospectively analyzed and they were set as the study group.The clinical data of 94 healthy pregnant women who underwent routine prenatal examination in the hospital during the same period were retrospectively analyzed and they were set as the control group.The levels of HbA1c and HOMA-IR in early pregnancy were compared between the two groups.The receiver operating characteristic(ROC)curve was drawn,the area under the curve(AUC)was calculated,and the predictive value of combined detection of HbA1c and HOMA-IR levels in early pregnancy for GDM.Results:The levels of HbA1c and HOMA-IR in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the AUC of single and combined detection of HbA1c and HOMA-IR levels in early pregnancy for predicting GDM was 0.716,0.775 and 0.848,separately,and the AUC of combined detection was the highest.Conclusions:The predictive value of combined detection of HbA1c and HOMA-IR levels in early pregnancy for GDM is higher than that of each individual test.

关 键 词：妊娠期糖尿病 孕早期 糖化血红蛋白 稳态模型评估胰岛素抵抗指数 预测 

分 类 号：R714.256[医药卫生—妇产科学]