结核后肺疾病患者患病率和影响因素的Meta分析  

The prevalence and influencing factors of post-tuberculosis lung disease:A Meta-analysis

作　　者：宋菲尔 毛燕君 夏秋月 周洋 林欢 Song Feier;Mao Yanjun;Xia Qiuyue;Zhou Yang;Lin Huan(School of Medicine,Tongji University,Shanghai 200092,China;Nursing Department,Shanghai Pulmonary Hospital Affiliated to Tongji University,Shanghai 200433,China)

机构地区：[1]同济大学医学院,上海200092 [2]同济大学附属上海市肺科医院护理部,上海200433

出　　处：《中国防痨杂志》2025年第3期322-330,共9页Chinese Journal of Antituberculosis

基　　金：上海申康医院发展中心市级医院诊疗技术推广及优化管理技术规范化管理和推广项目(SHDC22023236);同济大学医学院“护理学院(筹)学科建设三年行动计划”(JS2210104)。

摘　　要：目的:评价结核后肺疾病的患病率和影响因素。方法:计算机检索Cochrane Library、Medline、Embase、Web of Science、CINAHL、中国知网(CNKI)、万方数据知识服务平台、维普网(VIP)和中国生物医学文献服务系统(Sinomed)中收录的结核后肺疾病患者患病率和影响因素的相关文献,中文检索词包括:“肺结核/肺痨/肺消耗/结核后”“肺部疾病/肺疾病”“影响因素/危险因素/病因/相关因素”“病例对照研究/队列研究/横断面研究”;英文检索词包括:‘tuberculosis,pulmonary/pulmonary consumption/pulmonary phthis*/post-tb/post tuberculosis’‘lung diseases/disease,pulmonary’‘factor,risk/population at risk/risk scores/health correlates/factor,social risk/risk factor scores’‘case-control studies/cohort studies/cross-sectional studies’,检索时限为建库至2024年9月。由两名研究者独立进行筛选、评价文献及提取信息,并用Stata 17.0软件进行整合分析。结果:纳入12篇文献,共795890例患者。Meta分析显示,结核后肺疾病的患病率为33.2%[95%CI(12.0%~58.8%)]。受教育程度低(OR=2.32,95%CI:1.51~3.56,P<0.001)、低体质量指数(BMI)(SMD=-0.39,95%CI:-0.43~-0.34,P<0.001)、低收入(OR=1.19,95%CI:1.08~1.32,P=0.001)、城市居民(OR=1.13,95%CI:1.09~1.16,P<0.001)、并发糖尿病(OR=2.37,95%CI:2.19~2.55,P<0.001)、并发癌症(OR=2.01,95%CI:1.85~2.18,P<0.001)、住院次数多(SMD=0.44,95%CI:0.25~0.63,P<0.001)是结核后肺疾病的影响因素。结论:结核后肺疾病的影响因素众多,护理人员应针对影响因素进行预防,制定个体化干预措施,以减少结核后肺疾病的发生。Objective:To identify the prevalence and influencing factors of post-tuberculosis lung disease.Methods:Computerized search was performed for studies on prevalence and influencing factors of post-tuberculosis lung disease in CNKI,WANFANG DATA,VIP,CBM,Cochrane Library,Medline,Embase,Web of Science and CINAHL database from the time of database establishment to September 2024.Both Chinese and English search words were‘Tuberculosis,Pulmonary/Pulmonary Consumption/Pulmonary Phthis*/post-tb/post tuberculosis’‘Lung Diseases/Disease,Pulmonary’‘Factor,Risk/Population at Risk/Risk Scores/Health Correlates/Factor,Social Risk/Risk Factor Scores’‘Case-Control Studies/Cohort Studies/Cross-Sectional Studies’.Literature screening,quality assessment,and data extraction were performed independently by 2 investigators,and Meta-analysis was performed using Stata 17.0 software.Results:Twenty papers with a total of 795890 patients were included.Meta-analysis showed that the prevalence of post-tuberculosis lung disease was 33.2%(95%CI:12.0%-58.8%).Low education level(OR=2.32,95%CI:1.51-3.56,P<0.001),low BMI(SMD=-0.39,95%CI:-0.43--0.34,P<0.001),low income(OR=1.19,95%CI:1.08-1.32,P=0.001),urban residence(OR=1.13,95%CI:1.09-1.16,P<0.001),combined diabetes(OR=2.37,95%CI:2.19-2.55,P<0.001),combined cancer(OR=2.01,95%CI:1.85-2.18,P<0.001),times of hospitalization(SMD=0.44,95%CI:0.25-0.63,P<0.001)and other factors were influential factors for post-tuberculosis lung disease.Conclusion:There are many factors influencing post-tuberculosis lung disease,nursing staff should address the influencing factors and develop individualized interventions to reduce the occurrence of post-tuberculosis lung disease.

关 键 词：结核 肺 肺疾病 患病率 META分析 

分 类 号：R521[医药卫生—内科学]