自体细胞微移植提取物治疗雄激素性脱发的20例临床应用  

Clinical application of autologous cell micrograft extracts for the treatment of androgenetic alopecia in 20 cases

作　　者：Tan Pohching 冷冰 刘清[1] TAN Pohching;LENG Bing;LIU Qing(Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China;Huangpu Branch,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院,上海市200011 [2]上海交通大学医学院附属第九人民医院黄浦分院,上海市200011

出　　处：《组织工程与重建外科》2025年第1期50-54,共5页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：上海市科学技术委员会临床医学研究中心项目(22MC1940300)。

摘　　要：目的探索自体细胞微移植(Autologous cell micrograft,ACM)提取物治疗雄激素性秃发(Androgenetic alopecia,AGA)的有效性及安全性。方法回顾性分析AGA患者在脱发区域接受ACM提取物注射治疗后的情况。使用流式细胞仪分析ACM提取物悬浮液的细胞计数、存活率和细胞亚型。治疗后随访(12±2)周,通过治疗前后照片、皮肤镜图像、患者满意度调查问卷综合评价治疗的有效性。同时,观察注射区域有无感染、红肿、破溃等不良反应以评价治疗的安全性。结果本研究共纳入20例AGA病例。ACM提取物悬液中含有高达1×106的高活性细胞,主要为真皮乳头细胞。ACM提取物治疗后,脱发外观得到改善,头发覆盖显著增加。在皮肤镜检查中,整体毛发密度以及终毛/毳毛比例(T/V率)明显增加(P<0.05)。患者对治疗效果满意度高,反馈治疗后头皮油腻感和瘙痒感减少。另外,ACM提取物治疗有可能改善色素脱失。20例患者均未在随访期间出现治疗相关不良反应。结论ACM提取物治疗AGA安全有效,操作简单,技术易于掌握,有望成为AGA治疗的新方法。Objective To explore the efficacy and safety of autologous cell micrograft(ACM)extracts in the treatment of androgenetic alopecia(AGA).Methods The situation of AGA patients receiving ACM extract injection treatment in alopecia region was retrospectively analyzed.The cell count,survival rate and cell subtypes of ACM extract suspensions were analyzed by flow cytometry.The patients were followed up for(12±2)weeks after treatment.The effectiveness of the treatment was comprehensively evaluated by the photos before and after treatment,dermoscopy images and patient satisfaction questionnaire.At the same time,the injection area was observed for infection,swelling,rupture and other adverse reactions to evaluate the safety of treatment.Results The study included 20 patients with AGA.The suspension of ACM extract contained up to 106 highly viable cells,with DPs comprising the majority.Treatment with ACM extract resulted in significant improvement in hair loss appearance and a notable increase in hair coverage(P<0.05).Dermoscopic examination revealed a significant increase in overall hair density and a higher terminal-to-vellus hair ratio(T/V ratio).Patient satisfaction was high,with reports of reduced scalp oiliness and itching post-treatment.Additionally,ACM extract treatment can improve depigmentation.None of the 20 patients experienced any treatment-related adverse reactions during follow-up.Conclusion The application of ACM extract for the AGA treatment is safe and effective.This treatment method may serve as a novel approach to the AGA treatment as the injection of ACM extract was technologically simple and easy to use.

关 键 词：自体细胞微移植 雄激素性秃发 毛发再生 毛乳头细胞 CD44 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]