铜基纳米颗粒及含铜抗菌内植物的研究进展  

Research progress of copper-based nanoparticles and copper-containing antibacterial implants

作　　者：符光捷 黄磊云 白正林 朱斌 孟增东 FU Guangjie;HUANG Leiyun;BAI Zhenglin;ZHU Bin;MENG Zengdong(Medical College,Kunming University of Science and Technology,Kunming 650500,China;Department of Orthopaedics,First People’s Hospital of Yunnan Province,Kunming 650032,China;Yunnan Provincial Key Laboratory of Digital Orthopedics,Kunming 650032,China;Yunnan Orthopaedic and Sports Rehabilitation Clinical Medical Research Center,Kunming 650032,China;Yunnan Spine and Spinal Cord Disease Clinical Medical Center,Kunming 650032,China;College of Materials Science and Engineering,Kunming University of Science and Technology,Kunming 650031,China)

机构地区：[1]昆明理工大学医学院,云南省昆明市650500 [2]云南省第一人民医院骨科,云南省昆明市650032 [3]云南省数字骨科重点实验室,云南省昆明市650032 [4]云南省骨科与运动康复临床医学研究中心,云南省昆明市650032 [5]云南省脊柱脊髓疾病临床医学中心,云南省昆明市650032 [6]昆明理工大学材料科学与工程学院,云南省昆明市650031

出　　处：《组织工程与重建外科》2025年第1期93-100,共8页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：云南省卫生健康委员会医学领军人才培养计划(L-218004);云南省第一人民医院云南省数字骨科重点实验室平台开发项目(2024SGKFKT-02)。

摘　　要：由于过度和不合理地使用抗生素,细菌耐药性的发生率和耐药性的提高逐渐成为临床要面对的严峻问题,亟需寻找具有优秀抗菌能力、生物相容性优异且不易产生耐药性的抗菌剂以应用于临床。目前已有研究证明,铜基纳米颗粒本身尺寸小,比表面积大,抗菌性能优异,且不易产生耐药性,在未来有望替代抗生素。本文综述了铜基纳米颗粒的主要抗菌机制、生物相容性、生物防治以及骨科含铜内植物的研究进展,讨论了铜基纳米颗粒及含铜抗菌内植物现阶段存在的问题及挑战,并对这类抗菌材料的未来应用进行展望,以期推动铜基纳米颗粒及骨科含铜抗菌内植物的临床应用。Due to the excessive and unreasonable use of antibiotics,the incidence of bacterial resistance and the improvement of drug resistance have gradually become a serious problem faced by orthopedic medical workers.Therefore,it is necessary to find an antibacterial agent with excellent antibacterial ability,excellent biocompatibility and not easy to produce drug resistance,which can replace antibiotics for orthopedic clinical.At present,scholars at home and abroad have proved that copper-based nanoparticles have small size,large specific surface area,excellent antimicrobial performance and are not easy to produce drug resistance.In the future,there is hope to replace antibiotics in clinical applications.In this paper,the main antibacterial mechanisms,biocompatibility,biological control of copper-based nanoparticles and the research progress of orthopedic copper-containing implants were reviewed.The existing problems and challenges of copper-based nanoparticles and copper-containing antibacterial implants were discussed,and the future of such antibacterial materials was prospected,so as to promote the clinical application of copper-based nanoparticles and orthopedic copper-containing antibacterial implants.

关 键 词：铜基纳米颗粒 抗菌性能 生物相容性 生物防治 抗菌内植物 

分 类 号：R318.08[医药卫生—生物医学工程]