阿普米司特治疗家族性良性慢性天疱疮二例并文献复习  

Hailey-Hailey disease successfully treated with apremilast:two cases report and literature review

作　　者：刘雯慧 陈声利 施仲香[1,2] 刘红 LIU Wenhui;CHEN Shengli;SHI Zhongxiang;LIU Hong(Hospital for Skin Diseases,Shandong First Medical University,Jinan 250022,China;Shandong Provincial Institute of Dermatology and Venereology,Shandong Academy of Medical Sciences,Jinan 250022,China)

机构地区：[1]山东第一医科大学附属皮肤病医院,山东济南250022 [2]山东省皮肤病性病防治研究所,山东济南250022

出　　处：《中国麻风皮肤病杂志》2025年第3期180-183,共4页China Journal of Leprosy and Skin Diseases

基　　金：山东省皮肤性病学临床医学研究中心。

摘　　要：家族性良性慢性天疱疮是一种家族性遗传病,目前尚无统一的治疗方案。阿普米司特是一种口服小分子磷酸二酯酶4(PDE 4)抑制剂,国外有报道显示阿普米司特可显著改善家族性良性慢性天疱疮,国内暂无相关报道。本文国内首次报道二例对阿普米司特反应良好的家族性良性慢性天疱疮患者。Hailey-Hailey disease is a inheritary disease and there is currently no unified treatment standard.Apremilast,an oral small molecule phosphodiesterase 4(PDE 4) inhibitor,can significantly improve Hailey-Hailey disease according to foreign reports,but there are no relevant reports in China.This paper reported two patients with Hailey-Hailey disease who had a good response to apremilast in China reported for the first time,and relevant literature was reviewed.

关 键 词：阿普米司特 阿维A 家族性良性慢性天疱疮 PDE4 

分 类 号：R75[医药卫生—皮肤病学与性病学]