Inferring causal protein signalling networks from single-cell data based on parallel discrete artificial bee colony algorithm  

作　　者：Jinduo Liu Jihao Zhai Junzhong Ji 

机构地区：[1]Beijing Municipal Key Laboratory of Multimedia and Intelligent Software Technology,Beijing Institute of Artificial Intelligence,Faculty of Information Technology,Beijing University of Technology,Beijing,China

出　　处：《CAAI Transactions on Intelligence Technology》2024年第6期1587-1604,共18页智能技术学报(英文)

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:62106009,62276010;R&D Program of Beijing Municipal Education Commission,Grant/Award Numbers:KM202210005030,KZ202210005009。

摘　　要：Inferring causal protein signalling networks from human immune system cell data is a promising approach to unravel the underlying tissue signalling biology and dysfunction in diseased cells,which has attracted considerable attention within the bioinformatics field.Recently,Bayesian network(BN)techniques have gained significant popularity in inferring causal protein signalling networks from multiparameter single-cell data.However,current BN methods may exhibit high computational complexity and ignore interactions among protein signalling molecules from different single cells.A novel BN method is presented for learning causal protein signalling networks based on parallel discrete artificial bee colony(PDABC),named PDABC.Specifically,PDABC is a score-based BN method that utilises the parallel artificial bee colony to search for the global optimal causal protein signalling networks with the highest discrete K2 metric.The experimental results on several simulated datasets,as well as a previously published multi-parameter fluorescence-activated cell sorter dataset,indicate that PDABC surpasses the existing state-of-the-art methods in terms of performance and computational efficiency.

关 键 词：Bayesian network causal protein signaling networks parallel discrete artificial bee colony single-cell data 

分 类 号：TN9[电子电信—信息与通信工程]