嗜肺军团菌的生存策略:劫持小GTP酶调控宿主囊泡转运  

Survival Strategy of Legionella pneumophila:Hijacking Small GTPases to Manipulate Host Vesicle Trafficking

作　　者：李游智 陈涛涛 欧阳松应 张丹丹 LI Youzhi;CHEN Taotao;OUYANG Songying;ZHANG Dandan(College of Life Sciences,Fujian Normal University,Fuzhou 350117,China;Biomedical Research Center of South China,Fujian Normal University,Fuzhou 350117,China)

机构地区：[1]福建师范大学生命科学学院,福州350117 [2]福建师范大学南方生物医学研究中心,福州350117

出　　处：《中国细胞生物学学报》2025年第2期256-265,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金面上项目(批准号:82172287);福建省中青年教师教育科研项目(批准号:JAT220048)资助的课题。

摘　　要：作为军团菌病的病原体,嗜肺军团菌侵入宿主细胞后分泌330多个效应蛋白至宿主细胞,干扰宿主细胞的生命活动,建立其复制所需的场所—含军团菌吞噬泡(Legionella-containing vacuole,LCV)。LCV形成及成熟是嗜肺军团菌在宿主细胞内生存的必要条件。小GTP酶作为分子开关,参与细胞囊泡转运过程。近十几年来,大量研究表明小GTP酶在嗜肺军团菌招募宿主囊泡中发挥重要作用。嗜肺军团菌通过多个效应蛋白调控宿主小GTP酶的活性来操纵宿主囊泡运转过程,进而招募宿主囊泡。该文对小GTP酶、嗜肺军团菌及其调控小GTP酶的分子机制等方面进行了综述,以期为进一步理解嗜肺军团菌致病机制提供参考。L.pneumophila(Legionella pneumophila),as the causative agent of legionellosis,invades host cells and secretes more than 330 effector proteins to interfere with the life activities of host cells,thereby establishing a niche required for its replication,called the LCV(Legionella-containing vacuole).The formation and maturation of LCV is essential for the survival of L.pneumophila in host cells.The small GTPases,as a molecular switch,participates in the process of cellular vesicle transport.In the past decade,numerous studies have shown that host small GTPase proteins play an important role in the recruitment of host vesicles by L.pneumophila.L.pneumophila manipulates host vesicle trafficking by its secreted effector proteins involved in modulating the activity of host small GTPase,thus hijacking host vesicles.This study focuses on reviewing the small GTPase,L.pneumophila,and the molecular mechanisms by which L.pneumophila regulates the small GTPase,providing reference for further understanding of the pathogenesis of L.pneumophila.

关 键 词：嗜肺军团菌 效应蛋白 小GTP酶 囊泡转运 

分 类 号：R378[医药卫生—病原生物学]