热休克蛋白在糖尿病肾病中的作用及应用  

The Role and Application of Heat Shock Protein in Diabetes Nephropathy

作　　者：邓校征[1] 刘玲[1] 王文海[1] 温少瑾[1] 张琬婷 DENG Xiaozheng;LIU Ling;WANG Wenhai;WEN Shaojin;ZHANG Wanting(Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃省中医院,兰州730050

出　　处：《中国细胞生物学学报》2025年第2期276-282,共7页Chinese Journal of Cell Biology

基　　金：甘肃省名中医靳锋传承工作室建设项目(批准号:甘卫中医2023-62)资助的课题。

摘　　要：糖尿病肾病是糖尿病常见的并发症之一,主要由于长期的高血糖状态导致肾脏结构和功能发生改变。热休克蛋白是一类在应激条件下表达量增加的生物分子,具有保护细胞免受损伤的功能。在糖尿病肾病中,热休克蛋白发挥着重要作用,并有望作为诊断肾脏疾病的生物标志物和潜在治疗策略。研究证明,热休克蛋白可以通过减轻氧化应激、抑制炎症过程以及保护肾脏细胞免受损伤来发挥作用。利用热休克蛋白的抗氧化、抗炎和抗凋亡等机制,可以改善患者肾功能并延缓糖尿病肾病的进展。该文综述了热休克蛋白在糖尿病肾病中的研究现状,展望了未来研究方向,包括深入研究其分子机制、开发新的诊断方法和治疗策略。Diabetes nephropathy is one of the common complications of diabetes,which is mainly due to the long-term hyperglycemia state leading to changes in renal structure and function.HSPs(heat shock proteins)are a class of biomolecules that increase in expression under stress conditions and have the function of protecting cells from damage.HSPs play an important role in diabetes nephropathy,and are expected to be used as biomarkers and potential therapeutic strategies for renal diseases.Research has shown that heat shock proteins can play a role by reducing oxidative stress,inhibiting inflammatory processes,and protecting kidney cells from damage.It can improve renal function and delay the progress of diabetes nephropathy by using the antioxidant,anti-inflammatory and anti apoptosis mechanisms of heat shock protein.This article reviews the research status of heat shock protein in diabetes nephropathy,and looks forward to the future research directions,including in-depth study of its molecular mechanism,development of new diagnostic methods and treatment strategies.

关 键 词：糖尿病肾病 热休克蛋白 氧化应激 炎症 高糖 

分 类 号：R692.9[医药卫生—泌尿科学] R587.2[医药卫生—外科学]