脂滴在病毒感染中的功能研究进展  

Research Progress on the Function of Lipid Droplets in Virus Infection

作　　者：毛亚楠 高铭 周欣霓 尤冬雪 彭本群 王松[1,2] MAO Yanan;GAO Ming;ZHOU Xinni;YOU Dongxue;PENG Benqun;WANG Song(Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province,College of Animal Sciences,Fujian Agriculture and Forestry University,Fuzhou 350002,China;Key Laboratory of Fujian-Taiwan Animal Pathogen Biology,College of Animal Sciences,Fujian Agriculture and Forestry University,Fuzhou 350002,China)

机构地区：[1]福建农林大学动物科学学院,福建省畜禽病原感染与免疫学重点实验室,福州350002 [2]福建农林大学动物科学学院,闽台动物病原生物学福建省高校重点实验室,福州350002

出　　处：《畜牧兽医学报》2025年第2期513-522,共10页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：福建省自然科学基金(2020J06016);福建农林大学科技创新专项基金(KFb22063XA)。

摘　　要：脂滴是从内质网膜形成的一种独特的动态细胞器,主要负责细胞内中性脂质的储存。脂滴还与其它细胞器相互作用,参与脂质代谢、膜生物合成、细胞信号转导、免疫反应等生物学过程。近年来越来越多的研究表明,脂滴在病原微生物感染,尤其是病毒感染过程中发挥着重要作用。本文综述了脂滴与病毒之间的相互作用,包括脂滴对病毒复制周期的影响以及脂滴在调节抗病毒免疫反应中发挥的作用。了解脂滴在病毒感染中的功能对于深入揭示病毒的致病机制、研发新型抗病毒药物以及预防病毒传播具有重要意义。Lipid droplets(LDs)are unique and dynamic organelles formed from the endoplasmic reticulum membrane,primarily responsible for storing neutral lipids within cells.Additionally,LDs interact with other organelles and participate in biological processes such as lipid metabolism,membrane biogenesis,cell signaling,and immune responses,etc.In recent years,a growing body of evidence has shown that LDs play a critical role in pathogen infection,particularly in the process of viral infection.This review summarizes the interaction between LDs and viruses,including the impact of LDs on viral replication,and on their regulation of innate immune responses.Understanding the role of LDs in viral infection is of great importance for uncovering the pathogenic mechanisms of viruses,developing novel antiviral drugs,and preventing viral transmission.

关 键 词：脂滴 病毒 感染 复制 天然免疫 

分 类 号：S855.3[农业科学—临床兽医学]